Role of the satiety factor oleoylethanolamide in alcoholism

Ainhoa Bilbao; Antonia Serrano; Andrea Cippitelli; Francisco J. Pavón; Andrea Giuffrida; Juan Suárez; Nuria García-Marchena; Elena Baixeras; Raquel Gómez de Heras; Laura Orio; Francisco Alén; Roberto Ciccocioppo; Benjamin F. Cravatt; Loren H. Parsons; Daniele Piomelli; Fernando Rodríguez de Fonseca

doi:10.1111/adb.12276

Role of the satiety factor oleoylethanolamide in alcoholism

Ainhoa Bilbao, Antonia Serrano, Andrea Cippitelli, Francisco J. Pavón, Andrea Giuffrida, Juan Suárez, Nuria García-Marchena, Elena Baixeras, Raquel Gómez de Heras, Laura Orio, Francisco Alén, Roberto Ciccocioppo, Benjamin F. Cravatt, Loren H. Parsons, Daniele Piomelli, Fernando Rodríguez de Fonseca

Department of Pharmacology

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

Oleoylethanolamide (OEA) is a satiety factor that controls motivational responses to dietary fat. Here we show that alcohol administration causes the release of OEA in rodents, which in turn reduces alcohol consumption by engaging peroxisome proliferator-activated receptor-alpha (PPAR-α). This effect appears to rely on peripheral signaling mechanisms as alcohol self-administration is unaltered by intracerebral PPAR-α agonist administration, and the lesion of sensory afferent fibers (by capsaicin) abrogates the effect of systemically administered OEA on alcohol intake. Additionally, OEA is shown to block cue-induced reinstatement of alcohol-seeking behavior (an animal model of relapse) and reduce the severity of somatic withdrawal symptoms in alcohol-dependent animals. Collectively, these findings demonstrate a homeostatic role for OEA signaling in the behavioral effects of alcohol exposure and highlight OEA as a novel therapeutic target for alcohol use disorders and alcoholism.

Original language	English (US)
Pages (from-to)	859-872
Number of pages	14
Journal	Addiction Biology
Volume	21
Issue number	4
DOIs	https://doi.org/10.1111/adb.12276
State	Published - Jul 1 2016

Keywords

Alcohol self-administration
PPAR-α
alcoholism
oleoylethanolamide
relapse

ASJC Scopus subject areas

Medicine (miscellaneous)
Pharmacology
Psychiatry and Mental health

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10.1111/adb.12276

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Bilbao, A., Serrano, A., Cippitelli, A., Pavón, F. J., Giuffrida, A., Suárez, J., García-Marchena, N., Baixeras, E., Gómez de Heras, R., Orio, L., Alén, F., Ciccocioppo, R., Cravatt, B. F., Parsons, L. H., Piomelli, D., & Rodríguez de Fonseca, F. (2016). Role of the satiety factor oleoylethanolamide in alcoholism. Addiction Biology, 21(4), 859-872. https://doi.org/10.1111/adb.12276

Bilbao, A, Serrano, A, Cippitelli, A, Pavón, FJ, Giuffrida, A, Suárez, J, García-Marchena, N, Baixeras, E, Gómez de Heras, R, Orio, L, Alén, F, Ciccocioppo, R, Cravatt, BF, Parsons, LH, Piomelli, D & Rodríguez de Fonseca, F 2016, 'Role of the satiety factor oleoylethanolamide in alcoholism', Addiction Biology, vol. 21, no. 4, pp. 859-872. https://doi.org/10.1111/adb.12276

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abstract = "Oleoylethanolamide (OEA) is a satiety factor that controls motivational responses to dietary fat. Here we show that alcohol administration causes the release of OEA in rodents, which in turn reduces alcohol consumption by engaging peroxisome proliferator-activated receptor-alpha (PPAR-α). This effect appears to rely on peripheral signaling mechanisms as alcohol self-administration is unaltered by intracerebral PPAR-α agonist administration, and the lesion of sensory afferent fibers (by capsaicin) abrogates the effect of systemically administered OEA on alcohol intake. Additionally, OEA is shown to block cue-induced reinstatement of alcohol-seeking behavior (an animal model of relapse) and reduce the severity of somatic withdrawal symptoms in alcohol-dependent animals. Collectively, these findings demonstrate a homeostatic role for OEA signaling in the behavioral effects of alcohol exposure and highlight OEA as a novel therapeutic target for alcohol use disorders and alcoholism.",

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AU - Serrano, Antonia

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AU - Giuffrida, Andrea

AU - Suárez, Juan

AU - García-Marchena, Nuria

AU - Baixeras, Elena

AU - Gómez de Heras, Raquel

AU - Orio, Laura

AU - Alén, Francisco

AU - Ciccocioppo, Roberto

AU - Cravatt, Benjamin F.

AU - Parsons, Loren H.

AU - Piomelli, Daniele

AU - Rodríguez de Fonseca, Fernando

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Role of the satiety factor oleoylethanolamide in alcoholism

Abstract

Keywords

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