Role of the Antioxidant Melatonin in Regulating Autophagy and Mitophagy

Jose A. Boga, Ana Coto-Montes, Russel J Reiter

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Autophagy is an evolutionarily conserved and highly regulated lysosomal related process that degrades oxidatively damaged, aberrant macromolecules and organelles for the purpose of maintaining homeostasis during stress. Several types of autophagy, including pexophagy, ER-phagy, or ribophagy, have been described, based on which organelles are targeted for specific autophagic degradation. Among them, mitophagy plays a crucial role in the well-being of cells, since it is the major degradative pathway in mitochondrial turnover. Although autophagy is emerging as an important mediator of pathological responses and engages in cross-talk with ROS (reactive oxygen species) and RNS (reactive nitrogen species) in both cell signaling and protein damage, the role of antioxidants in the regulation of these processes has been sparingly investigated. Melatonin, which is a ubiquitously acting antioxidant with protective actions against oxidative stress, also exhibits beneficial effects against mitochondrial dysfunction, suggesting a relation to mitophagy. This chapter focuses on data and the most recent advances related to the role of melatonin in health and disease, on autophagy activation in general, and on mitophagy in particular.

Original languageEnglish (US)
Title of host publicationAutophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging
PublisherElsevier Inc.
Pages139-149
Number of pages11
Volume4
ISBN (Print)9780124055339, 9780124055285
DOIs
StatePublished - Jul 25 2014

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Keywords

  • Autophagy
  • Free radical theory of aging
  • Melatonin
  • Reactive nitrogen species
  • Reactive oxygen species

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)

Cite this

Boga, J. A., Coto-Montes, A., & Reiter, R. J. (2014). Role of the Antioxidant Melatonin in Regulating Autophagy and Mitophagy. In Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging (Vol. 4, pp. 139-149). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-405528-5.00008-0