Role of stent design and coatings on restenosis and thrombosis

Hidehiko Hara, Masato Nakamura, Julio C. Palmaz, Robert S. Schwartz

Research output: Contribution to journalReview articlepeer-review

135 Scopus citations

Abstract

More than 15 years have passed since stent technology was introduced by Sigwart et al. [U. Sigwart, J. Puel, V. Mirkovitch, F. Joffe, et al. Intravascular stents to prevent occlusion and restenosis after transluminal angioplasty. N. Engl. J. Med. 316 (1987) 701-706.] among interventional cardiologists. Recently drug eluting stents have assumed dominance in the interventional world as positive trial results revealed their efficacy for preventing restenosis. Stent design, delivery-vehicle materials, and drug properties affect the function of these stents. Stainless steel stents with tubular and multicellular design have proven superior to coil or hybrid stent models. This chapter describes stents which have subtle influences of modular design, metal coverage, strut thickness, strut shape, surface smoothness, and coating materials like an alloy composition.

Original languageEnglish (US)
Pages (from-to)377-386
Number of pages10
JournalAdvanced Drug Delivery Reviews
Volume58
Issue number3
DOIs
StatePublished - Jun 3 2006

Keywords

  • Drug eluting stent
  • Restenosis
  • Stent
  • Stent design

ASJC Scopus subject areas

  • Pharmaceutical Science

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