Role of sleep disturbance in chronic hepatitis C infection

Meghan D. Carlson, Robin C. Hilsabeck, Fatma Barakat, William Perry

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Chronic infection with the hepatitis C virus (CHC) is associated with physical and mental symptoms including fatigue and depression that adversely affect quality of life. A related complaint, sleep disturbance, has received little attention in the literature, with the exception of sleep changes noted in cirrhosis and end-stage liver disease. We present an overview of studies indicating sleep problems in patients with CHC, with about 60% to 65% of individuals reporting such complaints. Evidence suggests that impairments in sleep quality exist independent of antiviral therapy with interferon-α and prior to advanced stages of liver disease. Further investigation of sleep disturbance in CHC patients with a mild stage of liver disease may provide important information on disease course as well as allow additional opportunities for patient support.

Original languageEnglish (US)
Pages (from-to)25-29
Number of pages5
JournalCurrent Hepatitis Reports
Issue number1
StatePublished - Feb 2010


  • ESLD
  • HCV
  • Hepatitis C
  • Liver disease
  • Sleep

ASJC Scopus subject areas

  • Hepatology
  • Virology


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