TY - JOUR
T1 - Role of signaling molecules in mitochondrial stress response
AU - Hill, Shauna
AU - Sataranatarajan, Kavithalakshmi
AU - Van Remmen, Holly
N1 - Publisher Copyright:
© 2018 Hill, Sataranatarajan and Van Remmen.
PY - 2018/7/10
Y1 - 2018/7/10
N2 - Mitochondria are established essential regulators of cellular function and metabolism. Mitochondria regulate redox homeostasis, maintain energy (ATP) production through oxidative phosphorylation, buffer calcium levels, and control cell death through apoptosis. In addition to these critical cell functions, recent evidence supports a signaling role for mitochondria. For example, studies over the past few years have established that peptides released from the mitochondria mediate stress responses such as the mitochondrial unfolded protein response (UPRMT) through signaling to the nucleus. Mitochondrial damage or danger associated molecular patterns (DAMPs) provide a link between mitochondria, inflammation and inflammatory disease processes. Additionally, a new class of peptides generated by the mitochondria affords protection against age-related diseases in mammals. In this short review, we highlight the role of mitochondrial signaling and regulation of cellular activities through the mitochondrial UPRMT that signals to the nucleus to affect homeostatic responses, DAMPs, and mitochondrial derived peptides.
AB - Mitochondria are established essential regulators of cellular function and metabolism. Mitochondria regulate redox homeostasis, maintain energy (ATP) production through oxidative phosphorylation, buffer calcium levels, and control cell death through apoptosis. In addition to these critical cell functions, recent evidence supports a signaling role for mitochondria. For example, studies over the past few years have established that peptides released from the mitochondria mediate stress responses such as the mitochondrial unfolded protein response (UPRMT) through signaling to the nucleus. Mitochondrial damage or danger associated molecular patterns (DAMPs) provide a link between mitochondria, inflammation and inflammatory disease processes. Additionally, a new class of peptides generated by the mitochondria affords protection against age-related diseases in mammals. In this short review, we highlight the role of mitochondrial signaling and regulation of cellular activities through the mitochondrial UPRMT that signals to the nucleus to affect homeostatic responses, DAMPs, and mitochondrial derived peptides.
KW - Longevity
KW - Mitochondria
KW - Retrograde response
KW - Signaling peptides
KW - Stress response
UR - http://www.scopus.com/inward/record.url?scp=85049652696&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85049652696&partnerID=8YFLogxK
U2 - 10.3389/fgene.2018.00225
DO - 10.3389/fgene.2018.00225
M3 - Short survey
AN - SCOPUS:85049652696
VL - 9
JO - Frontiers in Genetics
JF - Frontiers in Genetics
SN - 1664-8021
IS - JUL
M1 - 225
ER -