Abstract
A 24-kDa protein was isolated from the outer membrane vesicles of Porphyromonas gingivalis W50. This protein, referred to as fibroblast- activating factor (FAF), was examined for its bone-resorptive ability by the rat long-bone assay and the mouse bone marrow cell culture system. FAF resulted in a significant release of 45Ca from cultured bones, as well as the formation of tartrate-resistant acid phosphatase-positive monocytes. These cultures were compared with control cells. FAF therefore might be considered a significant bacterially expressed protein which could affect and modulate the resorption or destruction of tissue and alveolar bone in the local periodontal environment.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3562-3564 |
| Number of pages | 3 |
| Journal | Infection and immunity |
| Volume | 61 |
| Issue number | 8 |
| State | Published - 1993 |
ASJC Scopus subject areas
- Parasitology
- Microbiology
- Immunology
- Infectious Diseases