Role of Porphyromonas gingivalis-derived fibroblast-activating factor in bone resorption

J. Mihara, T. Yoneda, S. C. Holt

Research output: Contribution to journalComment/debatepeer-review

5 Scopus citations


A 24-kDa protein was isolated from the outer membrane vesicles of Porphyromonas gingivalis W50. This protein, referred to as fibroblast- activating factor (FAF), was examined for its bone-resorptive ability by the rat long-bone assay and the mouse bone marrow cell culture system. FAF resulted in a significant release of 45Ca from cultured bones, as well as the formation of tartrate-resistant acid phosphatase-positive monocytes. These cultures were compared with control cells. FAF therefore might be considered a significant bacterially expressed protein which could affect and modulate the resorption or destruction of tissue and alveolar bone in the local periodontal environment.

Original languageEnglish (US)
Pages (from-to)3562-3564
Number of pages3
JournalInfection and immunity
Issue number8
StatePublished - 1993

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases


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