Role of polymorphisms in Adamantiades-Behçet's disease

Virginia G. Kaklamani, Maureen Sadim, Yvoni Koumantaki, Phedon Kaklamanis, Boris Pasche

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Objective. We previously showed that Adamantiades-Behçet's disease (A-BD) is associated with a lower incidence of malignancy compared with the general population. Transforming growth factor-β (TGF-β) has been shown to play a role in cartilage regeneration and is increased in patients with A-BD. We also found 2 functional polymorphisms of the TGF-β pathway, TGFBR1*6A and TGFB1*CC, that are associated with risk of malignancy. We tested whether incidence of these polymorphisms would differ in patients with A-BD compared with healthy controls of similar age and geographic location. Methods. We performed a case-control study including 139 cases and 128 controls from Greece. Cases and controls were genotyped for TGFBR1*6A and TGFB1*CC. Results. We found that cases had lower incidence of TGFBR1*6A compared with controls (11.3% vs 13.3%, respectively). Also, the incidence of TGFB1*CC was lower in cases than controls (24.6% vs 27.0%, respectively). These differences were not statistically significant. Conclusion. Although there is a suggestion that the lower incidence of TGFBR1*6A in A-BD patients may play a protective role against development of malignancy, larger studies would be needed to fully evaluate the role of TGF-β and its polymorphisms in A-BD.

Original languageEnglish (US)
Pages (from-to)2376-2378
Number of pages3
JournalJournal of Rheumatology
Volume35
Issue number12
DOIs
StatePublished - Dec 2008
Externally publishedYes

Keywords

  • Adamantiades-Behçet's disease
  • Cancer risk
  • Polymorphisms
  • Transforming growth factor-β

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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  • Cite this

    Kaklamani, V. G., Sadim, M., Koumantaki, Y., Kaklamanis, P., & Pasche, B. (2008). Role of polymorphisms in Adamantiades-Behçet's disease. Journal of Rheumatology, 35(12), 2376-2378. https://doi.org/10.3899/jrheum.080676