Role of phospholipid transfer protein in rabbit lung development

S. Kaushal, S. Ghosh, N. Sharma, S. N. Sanyal, S. Majumdar

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

A 36-kDa phospholipid transfer protein (PLT-PR), which preferentially transfers phosphatidyl choline (PC) compared to phosphatidyl inositol (PI), was purified 827-fold from rabbit lung homogenate. Incorporation of cholesterol in unilamellar vesicles reduced the PC transfer activity of PLTPR. Dipalmitoyl phosphatidyl choline uptake by alveolar type II cells was increased in the presence of the protein, and further enhanced in the presence of surfactant liposomes. However, a decrease in uptake was noted with cholesterol in host membranes. Incorporation of PI into host membranes had a low stimulatory effect on the process. All these effects were more pronounced in adult type II cells compared to premature, term and 3-day-old pups.

Original languageEnglish (US)
Pages (from-to)2098-2107
Number of pages10
JournalCellular and Molecular Life Sciences
Volume58
Issue number14
DOIs
StatePublished - Jan 1 2001

Keywords

  • Dipalmitoyl phosphatidyl choline
  • Phospholipid transfer protein
  • Respiratory distress syndrome
  • Surfactant

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology

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    Kaushal, S., Ghosh, S., Sharma, N., Sanyal, S. N., & Majumdar, S. (2001). Role of phospholipid transfer protein in rabbit lung development. Cellular and Molecular Life Sciences, 58(14), 2098-2107. https://doi.org/10.1007/PL00000839