Role of oxidative stress in neonatal respiratory distress syndrome

Lucia Marseglia, Gabriella D'Angelo, Roberta Granese, Raffaele Falsaperla, Russel J. Reiter, Giovanni Corsello, Eloisa Gitto

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations


Respiratory distress syndrome is the commonest respiratory disorder in preterm infants. Although it is well known that preterm birth has a key role, the mechanisms of lung injury have not been fully elucidated. The pathogenesis of this neonatal condition is based on the rapid formation of the oxygen reactive species, which surpasses the detoxification capacity of anti-oxidative defense system. The high reactivity of free radical leads to damage to a variety of molecules and may induce respiratory cell death. There is evidence that the oxidative stress involved in the physiopathology of this disease, is particularly related to oxygen supplementation, mechanical ventilation, inflammation/infection and diabetes. This narrative review summarizes what is known regarding the connection between oxidative stress and respiratory distress syndrome.

Original languageEnglish (US)
Pages (from-to)132-137
Number of pages6
JournalFree Radical Biology and Medicine
StatePublished - Oct 2019


  • Newborn
  • Oxidative stress
  • Prematurity
  • Respiratory distress syndrome
  • Ventilation

ASJC Scopus subject areas

  • Biochemistry
  • Physiology (medical)


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