Role of neuropeptide Y (NPY) in the regulation of reproduction: Study based on catfish model

Nishikant Subhedar, Archana Gaikwad, K. C. Biju, Subhash Saha

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Significance of NPY in the regulation of GnRH-LH axis was evaluated. Considerable NPY immunoreactivity was seen in the components like olfactory system, basal telencephalon, preoptic and tuberal areas, and the pituitary gland that serve as neuroanatomical substrates for processing reproductive information. Close anatomical association as well as colocalizations of NPY and GnRH were seen in the olfactory receptor neurons, olfactory nerve fibers and their terminals in the glomeruli, ganglion cells of nervus terminalis, medial olfactory tracts, fibers in the ventral telencephalon and pituitary. In the pituitary, NPY fibers seem to innervate the GnRH as well as LH cells. Intracranial administration of NPY resulted in significant increase in the GnRH immunoreactivity in all the components of the olfactory system. In the pituitary, NPY augmented the population of GnRH fibers and LH cells. HPLC analysis showed that salmon GnRH content in the olfactory organ, bulb, preoptic area+telencephalon and pituitary was also significantly increased following NPY treatment. NPY may play a role in positive regulation of GnRH throughout the neuraxis and also up-regulate the LH cells in the pituitary.

Original languageEnglish (US)
Pages (from-to)167-172
Number of pages6
JournalFish Physiology and Biochemistry
Issue number2-3
StatePublished - Apr 2005
Externally publishedYes


  • Forebrain
  • GnRH-LH axis
  • Immunocytochemistry
  • Olfactory system
  • Peptides
  • Teleosts

ASJC Scopus subject areas

  • Aquatic Science
  • Biochemistry
  • Physiology


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