Abstract
The norepinephrine (NE)-induced accumulation of cyclic AMP in incubated tissue slices of mouse lung was inhibited by chlorpromazine (CPZ) and to a lesser extent by haloperidol. In particulate lung fractions both agents blocked dopamine-sensitive adenylate cyclase to a greater degree than the NE-responsive enzyme. Again CPZ was more potent than haloperidol. Acute injections ( 1/2 -8 h) of the neuroleptics usually resulted in lower steady state levels of pulmonary cyclic AMP and cyclic GMP following rapid (0.5 sec) tissue inactivation by microwave irradiation. On a subchronic injection schedule, the in vivo levels of pulmonary cyclic AMP tended to increase.
Original language | English (US) |
---|---|
Pages (from-to) | 280-287 |
Number of pages | 8 |
Journal | Unknown Journal |
Volume | 17 |
Issue number | 5 |
DOIs | |
State | Published - Jan 1 1978 |
ASJC Scopus subject areas
- Pharmacology