Role of neuroleptic agents on mouse pulmonary cyclic nucleotide systems

G. C. Palmer; D. J. Jones; M. A. Medina; S. J. Palmer; W. B. Stavinoha

doi:10.1159/000136866

Role of neuroleptic agents on mouse pulmonary cyclic nucleotide systems

G. C. Palmer, D. J. Jones, M. A. Medina, S. J. Palmer, W. B. Stavinoha

Anesthesiology

Research output: Contribution to journal › Article › peer-review

Abstract

The norepinephrine (NE)-induced accumulation of cyclic AMP in incubated tissue slices of mouse lung was inhibited by chlorpromazine (CPZ) and to a lesser extent by haloperidol. In particulate lung fractions both agents blocked dopamine-sensitive adenylate cyclase to a greater degree than the NE-responsive enzyme. Again CPZ was more potent than haloperidol. Acute injections ( 1/2 -8 h) of the neuroleptics usually resulted in lower steady state levels of pulmonary cyclic AMP and cyclic GMP following rapid (0.5 sec) tissue inactivation by microwave irradiation. On a subchronic injection schedule, the in vivo levels of pulmonary cyclic AMP tended to increase.

Original language	English (US)
Pages (from-to)	280-287
Number of pages	8
Journal	Unknown Journal
Volume	17
Issue number	5
DOIs	https://doi.org/10.1159/000136866
State	Published - Jan 1 1978

ASJC Scopus subject areas

Pharmacology

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title = "Role of neuroleptic agents on mouse pulmonary cyclic nucleotide systems",

abstract = "The norepinephrine (NE)-induced accumulation of cyclic AMP in incubated tissue slices of mouse lung was inhibited by chlorpromazine (CPZ) and to a lesser extent by haloperidol. In particulate lung fractions both agents blocked dopamine-sensitive adenylate cyclase to a greater degree than the NE-responsive enzyme. Again CPZ was more potent than haloperidol. Acute injections ( 1/2 -8 h) of the neuroleptics usually resulted in lower steady state levels of pulmonary cyclic AMP and cyclic GMP following rapid (0.5 sec) tissue inactivation by microwave irradiation. On a subchronic injection schedule, the in vivo levels of pulmonary cyclic AMP tended to increase.",

author = "Palmer, {G. C.} and Jones, {D. J.} and Medina, {M. A.} and Palmer, {S. J.} and Stavinoha, {W. B.}",

year = "1978",

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doi = "10.1159/000136866",

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AU - Palmer, G. C.

AU - Jones, D. J.

AU - Medina, M. A.

AU - Palmer, S. J.

AU - Stavinoha, W. B.

PY - 1978/1/1

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N2 - The norepinephrine (NE)-induced accumulation of cyclic AMP in incubated tissue slices of mouse lung was inhibited by chlorpromazine (CPZ) and to a lesser extent by haloperidol. In particulate lung fractions both agents blocked dopamine-sensitive adenylate cyclase to a greater degree than the NE-responsive enzyme. Again CPZ was more potent than haloperidol. Acute injections ( 1/2 -8 h) of the neuroleptics usually resulted in lower steady state levels of pulmonary cyclic AMP and cyclic GMP following rapid (0.5 sec) tissue inactivation by microwave irradiation. On a subchronic injection schedule, the in vivo levels of pulmonary cyclic AMP tended to increase.

AB - The norepinephrine (NE)-induced accumulation of cyclic AMP in incubated tissue slices of mouse lung was inhibited by chlorpromazine (CPZ) and to a lesser extent by haloperidol. In particulate lung fractions both agents blocked dopamine-sensitive adenylate cyclase to a greater degree than the NE-responsive enzyme. Again CPZ was more potent than haloperidol. Acute injections ( 1/2 -8 h) of the neuroleptics usually resulted in lower steady state levels of pulmonary cyclic AMP and cyclic GMP following rapid (0.5 sec) tissue inactivation by microwave irradiation. On a subchronic injection schedule, the in vivo levels of pulmonary cyclic AMP tended to increase.

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