Role of neuroleptic agents on mouse pulmonary cyclic nucleotide systems

G. C. Palmer, D. J. Jones, M. A. Medina, S. J. Palmer, W. B. Stavinoha

Research output: Contribution to journalArticlepeer-review

Abstract

The norepinephrine (NE)-induced accumulation of cyclic AMP in incubated tissue slices of mouse lung was inhibited by chlorpromazine (CPZ) and to a lesser extent by haloperidol. In particulate lung fractions both agents blocked dopamine-sensitive adenylate cyclase to a greater degree than the NE-responsive enzyme. Again CPZ was more potent than haloperidol. Acute injections ( 1/2 -8 h) of the neuroleptics usually resulted in lower steady state levels of pulmonary cyclic AMP and cyclic GMP following rapid (0.5 sec) tissue inactivation by microwave irradiation. On a subchronic injection schedule, the in vivo levels of pulmonary cyclic AMP tended to increase.

Original languageEnglish (US)
Pages (from-to)280-287
Number of pages8
JournalUnknown Journal
Volume17
Issue number5
DOIs
StatePublished - Jan 1 1978

ASJC Scopus subject areas

  • Pharmacology

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