Role of mtDNA haplogroups in the prevalence of knee osteoarthritis in a southern Chinese population

Hezhi Fang, Xinwei Liu, Lijun Shen, Fengjie Li, Yihong Liu, Hongbo Chi, Huikai Miao, Jianxin Lu, Yidong Bai

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Mitochondrial DNA (mtDNA) has been implicated in various human degenerative diseases. However, the role of mtDNA in Osteoarthritis (OA) is less known. To investigate whether mtDNA haplogroups contribute to the prevalence of knee OA, we have carried out a comprehensive case-control study on 187 knee OA patients and 420 geographically matched controls in southern China. OA patients were classified on the Kellgren/Lawrence scale from two to four for the disease severity study and the data were analyzed by adjusting for age and sex. We found that patients with haplogroup G (OR = 3.834; 95% CI 1.139, 12.908; p = 0.03) and T16362C (OR = 1.715; 95% CI 1.174, 2.506; p = 0.005) exhibited an increased risk of OA occurrence. Furthermore, patients carrying haplogroup G had a higher severity progression of knee OA (OR = 10.870; 95% CI 1.307, 90.909; p = 0.007). On the other hand, people with haplogroup B/B4 (OR = 0.503; 95% CI 0.283, 0.893; p = 0.019)/(OR = 0.483; 95% CI 0.245, 0.954; p = 0.036) were less susceptible for OA occurrence. Interestingly, we found OA patients also exhibited a general increase in mtDNA content. Our study indicates that the mtDNA haplogroup plays a role in modulating OA development.

Original languageEnglish (US)
Pages (from-to)2646-2659
Number of pages14
JournalInternational journal of molecular sciences
Volume15
Issue number2
DOIs
StatePublished - Feb 14 2014

Keywords

  • Copy number
  • Haplogroup
  • Mitochondria
  • Osteoarthritis

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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