Role of mitochondria in the regulation of kidney function and metabolism in type 2 diabetes

Xianlin Han, Yuguang Shi, Maggie Diamond-Stanic, Kumar Sharma

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The kidney is the organ that regulates salt and water metabolism and finely tunes levels of electrolytes and minerals in the blood. This role of the kidney has allowed organisms to face many environmental challenges, such as reduced availability of sodium, potassium, and water. In addition to the regulation of inorganic molecules and water balance, the kidney is a major regulator of organic substances. These include organic nutrient sources such as sugars, fats, and proteins and likely many other organic acids that are byproducts of the metabolism of the mammalian host and also the microbiome. With this larger recognition of the role of the kidney, it is not surprising that the kidney is a susceptible target in nutrient stress conditions, with the prime example being type 2 diabetes.

Original languageEnglish (US)
Title of host publicationMitochondria in Obesity and Type 2 Diabetes
Subtitle of host publicationComprehensive Review on Mitochondrial Functioning and Involvement in Metabolic Diseases
PublisherElsevier
Pages287-300
Number of pages14
ISBN (Electronic)9780128117521
ISBN (Print)9780128118597
DOIs
StatePublished - Jan 1 2019

Keywords

  • Cardiolipin
  • Kidney function
  • Metabolism
  • Mitochondria
  • Oxidative phosphorylation
  • Type 2 diabetes

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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  • Cite this

    Han, X., Shi, Y., Diamond-Stanic, M., & Sharma, K. (2019). Role of mitochondria in the regulation of kidney function and metabolism in type 2 diabetes. In Mitochondria in Obesity and Type 2 Diabetes: Comprehensive Review on Mitochondrial Functioning and Involvement in Metabolic Diseases (pp. 287-300). Elsevier. https://doi.org/10.1016/B978-0-12-811752-1.00012-2