Role of Histone Methylation in Myeloid Malignancies -Review

Yu Nan Li; Meng Yao Sheng; Feng Chun Yang; Yuan Zhou

doi:10.7534/j.issn.1009-2137.2017.01. 042

Role of Histone Methylation in Myeloid Malignancies -Review

Yu Nan Li, Meng Yao Sheng, Feng Chun Yang, Yuan Zhou

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

Histone methylation is one of the important epigenetic regulatory mechanisms, and plays a significant role in a variety of physiological and pathological processes. Many recent studies have shown that abnormalities of histone methylation are closely related with the initiation and progression of myeloid malignancies. The reversibility of histone methylation provides a broad prospect for the discovery and application of specific small molecule drugs. This review summarizes the recent progresses in this area and mainly focuses on the correlation of histone methylation with myeloid malignancies.

Original language	English (US)
Pages (from-to)	235-239
Number of pages	5
Journal	Zhongguo shi yan xue ye xue za zhi
Volume	25
Issue number	1
DOIs	https://doi.org/10.7534/j.issn.1009-2137.2017.01. 042
State	Published - Feb 1 2017
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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abstract = "Histone methylation is one of the important epigenetic regulatory mechanisms, and plays a significant role in a variety of physiological and pathological processes. Many recent studies have shown that abnormalities of histone methylation are closely related with the initiation and progression of myeloid malignancies. The reversibility of histone methylation provides a broad prospect for the discovery and application of specific small molecule drugs. This review summarizes the recent progresses in this area and mainly focuses on the correlation of histone methylation with myeloid malignancies.",

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AU - Sheng, Meng Yao

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AU - Zhou, Yuan

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N2 - Histone methylation is one of the important epigenetic regulatory mechanisms, and plays a significant role in a variety of physiological and pathological processes. Many recent studies have shown that abnormalities of histone methylation are closely related with the initiation and progression of myeloid malignancies. The reversibility of histone methylation provides a broad prospect for the discovery and application of specific small molecule drugs. This review summarizes the recent progresses in this area and mainly focuses on the correlation of histone methylation with myeloid malignancies.

AB - Histone methylation is one of the important epigenetic regulatory mechanisms, and plays a significant role in a variety of physiological and pathological processes. Many recent studies have shown that abnormalities of histone methylation are closely related with the initiation and progression of myeloid malignancies. The reversibility of histone methylation provides a broad prospect for the discovery and application of specific small molecule drugs. This review summarizes the recent progresses in this area and mainly focuses on the correlation of histone methylation with myeloid malignancies.

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Role of Histone Methylation in Myeloid Malignancies -Review

Abstract

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