Role of histone acetyltransferases MOF and Tip60 in genome stability

Ulfat Syed Mir, Audesh Bhat, Arjamand Mushtaq, Shruti Pandita, Mohammad Altaf, Tej K. Pandita

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

The accurate repair of DNA damage specifically the chromosomal double-strand breaks (DSBs) arising from exposure to physical or chemical agents, such as ionizing radiation (IR) and radiomimetic drugs is critical in maintaining genomic integrity. The DNA DSB response and repair is facilitated by hierarchical signaling networks that orchestrate chromatin structural changes specifically histone modifications which impact cell-cycle checkpoints through enzymatic activities to repair the broken DNA ends. Various histone posttranslational modifications such as phosphorylation, acetylation, methylation and ubiquitylation have been shown to play a role in DNA damage repair. Recent studies have provided important insights into the role of histone-specific modifications in sensing DNA damage and facilitating the DNA repair. Histone modifications have been shown to determine the pathway choice for repair of DNA DSBs. This review will summarize the role of important histone acetyltransferases MOF and Tip60 mediated acetylation in repair of DNA DSBs in eukaryotic cells.

Original languageEnglish (US)
Article number103205
JournalDNA Repair
Volume107
DOIs
StatePublished - Nov 2021
Externally publishedYes

Keywords

  • DNA DSB repair
  • Histone acetylation
  • Histone acetyltransferases
  • MOF
  • TIP60

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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