Role of GABAA receptors in the ethanol-mediated inhibition of extracellular signal-regulated kinase

Haviryaji S.G. Kalluri, Maharaj K. Ticku

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

In the present study, we demonstrate the involvement of GABAA receptors in the ethanol-mediated modulation of extracellular signal-regulated kinases (ERK). Intraperitoneal (i.p.) administration of ethanol (3.5 g), flurazepam (75 mg) or (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d] cycloheptane-5,10-iminemaleate (MK-801) (0.4 mg/kg body weight) decreased, while picrotoxin (10 mg/kg body weight) increased, the phosphorylation of ERK following 10 min of their injection. However, the picrotoxin-induced phosphorylation of ERK was inhibited by ethanol, but was not affected by MK-801. These results indicate that ethanol's inhibitory effect on ERK phosphorylation may involve the modulation of GABAA receptor function.

Original languageEnglish (US)
Pages (from-to)51-54
Number of pages4
JournalEuropean Journal of Pharmacology
Volume451
Issue number1
DOIs
StatePublished - Sep 6 2002

Keywords

  • Ethanol
  • GABA (γ-amino butyric acid)
  • MAP (mitogen-activated protein) kinase

ASJC Scopus subject areas

  • Pharmacology

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