Role of foetal adrenocorticotrophin during parturition in sheep

Lesley H. Rees, P. M.B. Jack, A. L. Thomas, P. W. Nathanielsz

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

IT is now well accepted that the lamb foetus plays an important role in the mechanisms which initiate its own delivery. This conclusion is based on several experimental observations. Foetal hypophysectomy or adrenalectomy delays parturition1,2; infusions of adrenocorticotrophin (ACTH) or cortisol, which is the major glucocorticoid in this species, will precipitate premature delivery when infused into the foetus3; normal delivery is preceded by an increase in the concentration of corticosteroids in the foetal blood 4,5 and an increased production of cortisol by the foetal adrenal6.

Original languageEnglish (US)
Pages (from-to)274-275
Number of pages2
JournalNature
Volume253
Issue number5489
DOIs
StatePublished - Dec 1 1975
Externally publishedYes

ASJC Scopus subject areas

  • General

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