Role of foetal adrenocorticotrophin during parturition in sheep

Lesley H. Rees; P. M.B. Jack; A. L. Thomas; P. W. Nathanielsz

doi:10.1038/253274a0

Role of foetal adrenocorticotrophin during parturition in sheep

Lesley H. Rees, P. M.B. Jack, A. L. Thomas, P. W. Nathanielsz

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Abstract

IT is now well accepted that the lamb foetus plays an important role in the mechanisms which initiate its own delivery. This conclusion is based on several experimental observations. Foetal hypophysectomy or adrenalectomy delays parturition^1,2; infusions of adrenocorticotrophin (ACTH) or cortisol, which is the major glucocorticoid in this species, will precipitate premature delivery when infused into the foetus³; normal delivery is preceded by an increase in the concentration of corticosteroids in the foetal blood ^4,5 and an increased production of cortisol by the foetal adrenal⁶.

Original language	English (US)
Pages (from-to)	274-275
Number of pages	2
Journal	Nature
Volume	253
Issue number	5489
DOIs	https://doi.org/10.1038/253274a0
State	Published - Dec 1 1975
Externally published	Yes

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title = "Role of foetal adrenocorticotrophin during parturition in sheep",

abstract = "IT is now well accepted that the lamb foetus plays an important role in the mechanisms which initiate its own delivery. This conclusion is based on several experimental observations. Foetal hypophysectomy or adrenalectomy delays parturition1,2; infusions of adrenocorticotrophin (ACTH) or cortisol, which is the major glucocorticoid in this species, will precipitate premature delivery when infused into the foetus3; normal delivery is preceded by an increase in the concentration of corticosteroids in the foetal blood 4,5 and an increased production of cortisol by the foetal adrenal6.",

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AU - Rees, Lesley H.

AU - Jack, P. M.B.

AU - Thomas, A. L.

AU - Nathanielsz, P. W.

PY - 1975/12/1

Y1 - 1975/12/1

N2 - IT is now well accepted that the lamb foetus plays an important role in the mechanisms which initiate its own delivery. This conclusion is based on several experimental observations. Foetal hypophysectomy or adrenalectomy delays parturition1,2; infusions of adrenocorticotrophin (ACTH) or cortisol, which is the major glucocorticoid in this species, will precipitate premature delivery when infused into the foetus3; normal delivery is preceded by an increase in the concentration of corticosteroids in the foetal blood 4,5 and an increased production of cortisol by the foetal adrenal6.

AB - IT is now well accepted that the lamb foetus plays an important role in the mechanisms which initiate its own delivery. This conclusion is based on several experimental observations. Foetal hypophysectomy or adrenalectomy delays parturition1,2; infusions of adrenocorticotrophin (ACTH) or cortisol, which is the major glucocorticoid in this species, will precipitate premature delivery when infused into the foetus3; normal delivery is preceded by an increase in the concentration of corticosteroids in the foetal blood 4,5 and an increased production of cortisol by the foetal adrenal6.

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Role of foetal adrenocorticotrophin during parturition in sheep

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