Role of cytokines in bone resorption

G. R. Mundy

Research output: Contribution to journalArticlepeer-review

72 Scopus citations

Abstract

Osteoclastic bone resorption is modulated in humans by powerful osteotropic factors which are generated in the immediate vicinity of bone resorbing surfaces. These factors are released from marrow mononuclear cells and from some bone cells, and some are actually incorporated into the noncollagenous bone matrix from where they are released when bone is resorbed. They are likely important not only in the control of normal bone remodeling, but also in a number of disease states associated with disordered remodeling. In this review, current concepts of the effects of these factors on cells in the osteoclast lineage will be discussed.

Original languageEnglish (US)
Pages (from-to)296-300
Number of pages5
JournalJournal of Cellular Biochemistry
Volume53
Issue number4
DOIs
StatePublished - 1993

Keywords

  • bone resorption
  • cytokines
  • osteoclasts
  • src

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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