Role of CTGF in Sensitivity to Hyperthermia in Ovarian and Uterine Cancers

Hiroto Hatakeyama, Sherry Y. Wu, Yasmin A. Lyons, Sunila Pradeep, Wanqin Wang, Qian Huang, Karem A. Court, Tao Liu, Song Nie, Cristian Rodriguez-Aguayo, Fangrong Shen, Yan Huang, Takeshi Hisamatsu, Takashi Mitamura, Nicholas Jennings, Jeajun Shim, Piotr L. Dorniak, Lingegowda S. Mangala, Marco Petrillo, Vladislav A. PetyukAthena A. Schepmoes, Anil K. Shukla, Madeline Torres-Lugo, Ju Seog Lee, Karin D. Rodland, Anna Fagotti, Gabriel Lopez-Berestein, Chun Li, Anil K. Sood

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Even though hyperthermia is a promising treatment for cancer, the relationship between specific temperatures and clinical benefits and predictors of sensitivity of cancer to hyperthermia is poorly understood. Ovarian and uterine tumors have diverse hyperthermia sensitivities. Integrative analyses of the specific gene signatures and the differences in response to hyperthermia between hyperthermia-sensitive and -resistant cancer cells identified CTGF as a key regulator of sensitivity. CTGF silencing sensitized resistant cells to hyperthermia. CTGF small interfering RNA (siRNA) treatment also sensitized resistant cancers to localized hyperthermia induced by copper sulfide nanoparticles and near-infrared laser in orthotopic ovarian cancer models. CTGF silencing aggravated energy stress induced by hyperthermia and enhanced apoptosis of hyperthermia-resistant cancers.

Original languageEnglish (US)
Pages (from-to)1621-1631
Number of pages11
JournalCell Reports
Volume17
Issue number6
DOIs
StatePublished - Nov 1 2016
Externally publishedYes

Keywords

  • CTGF
  • DOPC-liposome
  • copper sulfide nanoparticle
  • hyperthermia
  • ovarian cancer
  • thermosensitivity

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology

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