Role of caveolin-1 in asthma and chronic inflammatory respiratory diseases

Simon G. Royce, Claude Jourdan Le Saux

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Caveolin-1 (Cav-1) is the major protein present in invaginations of the plasma membrane of cells known as caveolae. Cav-1 is expressed in numerous resident and inflammatory cells implicated in the pathogenesis of asthma and chronic inflammatory respiratory diseases including chronic obstructive pulmonary disease. A remarkable repertoire of functions has been identified for Cav-1 and these extend to, and have relevance to, asthma and chronic inflammatory respiratory diseases. Important processes influenced by Cav-1 include inflammation, fibrosis, smooth muscle contractility, regulation of apoptosis and cell senescence as well as epithelial barrier function and homeostasis. A better understanding of Cav-1 may be useful in developing new therapies for chronic inflammatory respiratory diseases.

Original languageEnglish (US)
Pages (from-to)339-347
Number of pages9
JournalExpert Review of Respiratory Medicine
Volume8
Issue number3
DOIs
StatePublished - Jun 2014

Keywords

  • airway hyperresponsiveness
  • airway remodeling
  • asthma
  • caveolae
  • caveolin-1
  • chronic obstructive pulmonary disease
  • fibrosis
  • inflammation
  • lung

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine
  • Public Health, Environmental and Occupational Health

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