TY - JOUR
T1 - Role of array comparative genomic hybridization in investigation of cytogenetic causes of pregnancy loss
AU - Velagaleti, Gopalrao V.N.
AU - Moore, Charleen M.
PY - 2011/9
Y1 - 2011/9
N2 - Loss of a pregnancy is a distressing event for the parents involved, and recurrent miscarriages are even more so. At least 10% to 15% of recognized pregnancies end in miscarriage, with most losses occurring in the first trimester. The incidence of recurrent miscarriages ranges from 0.5% to 3%. Despite thorough evaluations, the etiology of recurrent miscarriages remains unknown in approximately 50% of the cases. Overall, a chromosome abnormality is identified in the products of conception in approximately 50% to 70% of miscarriages. Although recent advances in the last decade have significantly increased the ability to identify and characterize the chromosome abnormalities causing pregnancy loss, several limitations still remain. With the advent of recent technical advances such as microarray-based comparative genomic hybridization (a CGH), the prevalence of cytogenetic abnormalities identified in products of conception or intrauterine fetal demise has increased significantly over conventional chromosome analysis and/or fluorescence in situ hybridization. In this brief review, we will discuss the technique of a CGH, the advantages of a CGH technology over conventional methods, and the limitations of the technology, and then we will summarize the few available studies to date.
AB - Loss of a pregnancy is a distressing event for the parents involved, and recurrent miscarriages are even more so. At least 10% to 15% of recognized pregnancies end in miscarriage, with most losses occurring in the first trimester. The incidence of recurrent miscarriages ranges from 0.5% to 3%. Despite thorough evaluations, the etiology of recurrent miscarriages remains unknown in approximately 50% of the cases. Overall, a chromosome abnormality is identified in the products of conception in approximately 50% to 70% of miscarriages. Although recent advances in the last decade have significantly increased the ability to identify and characterize the chromosome abnormalities causing pregnancy loss, several limitations still remain. With the advent of recent technical advances such as microarray-based comparative genomic hybridization (a CGH), the prevalence of cytogenetic abnormalities identified in products of conception or intrauterine fetal demise has increased significantly over conventional chromosome analysis and/or fluorescence in situ hybridization. In this brief review, we will discuss the technique of a CGH, the advantages of a CGH technology over conventional methods, and the limitations of the technology, and then we will summarize the few available studies to date.
KW - FISH
KW - Pregnancy loss
KW - a CGH
KW - chromosome abnormalities
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U2 - 10.1097/PCR.0b013e3182298817
DO - 10.1097/PCR.0b013e3182298817
M3 - Review article
AN - SCOPUS:80052508113
SN - 1082-9784
VL - 16
SP - 214
EP - 221
JO - Pathology Case Reviews
JF - Pathology Case Reviews
IS - 5
ER -