@article{191d7700e3b64f2dbc437cd4ccbc313f,
title = "Role of adipokines and cytokines in obesity-associated breast cancer: Therapeutic targets",
abstract = "Obesity is the cause of a large proportion of breast cancer incidences and mortality in post-menopausal women. In obese people, elevated levels of various growth factors such as insulin and insulin-like growth factors (IGFs) are found. Elevated insulin level leads to increased secretion of estrogen by binding to the circulating sex hormone binding globulin (SHBG). The increased estrogen-mediated downstream signaling favors breast carcinogenesis. Obesity leads to altered expression profiles of various adipokines and cytokines including leptin, adiponectin, IL-6, TNF-α and IL-1β. The increased levels of leptin and decreased adiponectin secretion are directly associated with breast cancer development. Increased levels of pro-inflammatory cytokines within the tumor microenvironment promote tumor development. Efficacy of available breast cancer drugs against obesity-associated breast cancer is yet to be confirmed. In this review, we will discuss different adipokine- and cytokine-mediated molecular signaling pathways involved in obesity-associated breast cancer, available therapeutic strategies and potential therapeutic targets for obesity-associated breast cancer.",
keywords = "Adiponectin, Breast cancer, Cytokines, Leptin, Obesity",
author = "Sajid Khan and Samriddhi Shukla and Sonam Sinha and Meeran, \{Syed Musthapa\}",
note = "Funding Information: Syed Musthapa Meeran Ph.D is currently a senior scientist at the Division of Endocrinology of CSIR-Central Drug Research Institute. In his doctoral work, he studied the role of asbestos and other biomass pollutants-mediated genetic and cytogentic changes in the pulmonary system. To further in his postdoctoral study, he evaluated the role of inflammatory cytokines for the skin cancer risk at the Department of Dermatology, University of Alabama at Birmingham. Later he became a faculty at the Department of Biology, University of Alabama at Birmingham, where he studied the epigenetic and chemoprevention of breast cancer. He is currently working on the novel genetic and epigenetic targets for breast and lung cancer prevention as well as therapy with bioactive dietary supplements. His research interest are also focused on the role of various cytokine and chemokine mediated intra cellular signaling in the cancer progression, especially breast cancer. Sajid Khan obtained his Masters degree in Biotechnology from Aligarh Muslim University, Aligarh, India in 2011. Currently, he is working as a doctoral research fellow under the guidance of Dr. Syed Musthapa Meeran in the Endocrinology Division of CSIR-Central Drug Research Institute, Lucknow, India. His research work is primarily focused on the role of leptin and adiponectin in obesity-associated breast cancer. He also obtained Senior Research Fellowship (CSIR-SRF) from the Council of Scientific and Industrial Research, New Delhi, India for his doctoral study. Samriddhi Shukla has received her Masters degree in Biotechnology from Dr. R.M.L. Avadh University, Faizabad, India with university ranking and gold medal. She is currently pursuing her doctoral research under the mentorship of Dr. Syed Musthapa Meeran, CSIR-Central Drug Research Institute, Lucknow, India. Her research work mainly focuses on the genetics and epigenetics of lung cancer. She also obtained Senior Research Fellowship (CSIR-SRF) from the Council of Scientific and Industrial Research, New Delhi, India for her doctoral research work. Sonam Sinha earned her Masters in Biotechnology from AMITY University, Lucknow, India in 2011. She is currently engaged as a Project Assistant under the supervision of Dr. Syed Musthapa Meeran at CSIR-Central Drug Research Institute, Lucknow, India. Her research interest is mainly focused on studying novel genetic and epigenetic targets for breast cancer prevention and therapy with bioactive dietary supplements. Funding Information: This work was supported by the EpiHeD-Network Scheme (BSC0118) and Research fellowship grants (SK, SS) from the Council of Scientific and Industrial Research (CSIR), Government of India, India . Part of this work was also supported by grants to S.M.M. from the Science \& Engineering Research Board (SERB), New Delhi, India . We thank Ms. Isha Soni for her assistance in proof-reading the manuscript. CSIR-CDRI communication Number-8554. No conflict of interest. ",
year = "2013",
month = dec,
doi = "10.1016/j.cytogfr.2013.10.001",
language = "English (US)",
volume = "24",
pages = "503--513",
journal = "Cytokine and Growth Factor Reviews",
issn = "1359-6101",
publisher = "Elsevier Ltd",
number = "6",
}