Role in vivo for gamma interferon in control of pneumonia caused by Chlamydia trachomatis in mice

D. M. Williams, G. I. Byrne, B. Grubbs, T. J. Marshal, J. Schachter

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

In a model of pneumonia caused by murine Chlamydia trachomatis, depletion experiments with monoclonal antibody to gamma interferon (IFN-γ) made mice more susceptible. Repletion experiments giving exogenous recombinant murine IFN-γ were not consistently protective. IFN-γ may be necessary but not sufficient in host defense against the organism.

Original languageEnglish (US)
Pages (from-to)3004-3006
Number of pages3
JournalInfection and immunity
Volume56
Issue number11
StatePublished - 1988

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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