Rod photoresponse kinetics limit temporal contrast sensitivity in mesopic vision

Yumiko Umino, Ying Guo, Ching Kang Chen, Rose Pasquale, Eduardo Solessio

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

The mammalian visual system operates over an extended range of ambient light levels by switching between rod and cone photoreceptors. Rod-driven vision is sluggish, highly sensitive, and operates in dim or scotopic lights, whereas cone-driven vision is brisk, less sensitive, and operates in bright or photopic lights. At intermediate or mesopic lights, vision transitions seamlessly from rod-driven to cone-driven, despite the profound differences in rod and cone response dynamics. The neural mechanisms underlying such a smooth handoff are not understood. Using an operant behavior assay, electrophysiological recordings, and mathematical modeling we examined the neural underpinnings of the mesopic visual transition in mice of either sex.Wefound that rods, but not cones, drive visual sensitivity to temporal light variations overmuchof the mesopic range. Surprisingly, speeding up rod photoresponse recovery kinetics in transgenic mice improved visual sensitivity to slow temporal variations, in the range where perceptual sensitivity is governed by Weber’s law of sensation. In contrast, physiological processes acting downstream from phototransduction limit sensitivity to high frequencies and temporal resolution. We traced the paradoxical control of visual temporal sensitivity to rod photoresponses themselves. A scenario emerges where perceptual sensitivity is limited by: (1) the kinetics of neural processes acting downstream from phototransduction in scotopic lights, (2) rod response kinetics in mesopic lights, and (3) cone response kinetics as light levels rise into the photopic range.

Original languageEnglish (US)
Pages (from-to)3041-3056
Number of pages16
JournalJournal of Neuroscience
Volume39
Issue number16
DOIs
StatePublished - Apr 17 2019
Externally publishedYes

Keywords

  • ERG
  • Mesopic vision
  • Mouse
  • Operant behavior
  • Temporal resolution
  • Weber adaptation

ASJC Scopus subject areas

  • General Neuroscience

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