RNA expression of human telomerase subunits TR and TERT is differentially affected by melatonin receptor agonists in the MCF-7 tumor cell line

Mercedes M. Leon-Blanco, Juan M. Guerrero, Russel J Reiter, David Pozo

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Original languageEnglish
Pages (from-to)73-80
Number of pages8
JournalCancer Letters
Volume216
Issue number1
DOIs
StatePublished - Dec 8 2004

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Melatonin Receptors
Telomerase
MCF-7 Cells
Tumor Cell Line
S 20098
RNA
Nuclear Envelope
Melatonin
Cytoplasmic and Nuclear Receptors
Catalytic Domain
Breast Neoplasms
Membranes

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

Cite this

RNA expression of human telomerase subunits TR and TERT is differentially affected by melatonin receptor agonists in the MCF-7 tumor cell line. / Leon-Blanco, Mercedes M.; Guerrero, Juan M.; Reiter, Russel J; Pozo, David.

In: Cancer Letters, Vol. 216, No. 1, 08.12.2004, p. 73-80.

Research output: Contribution to journalArticle

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abstract = "The RNA expression levels of human catalytic subunit (TERT) and the RNA subunit (TR) of telomerase were analysed after treatment with the agonists of the membrane receptor (S 20098) and the nuclear receptor (CGP 52608) for melatonin in the MCF-7 human breast tumor cell line. Neither membrane nor nuclear signalling affected the RNA steady-state levels of the TR subunit of telomerase. On the contrary, we observed a significant decreased in the RNA levels of TERT after treatment with CGP 52608 while S 20098 produced a significant increase in the RNA levels of TERT. These results support a cross-talk between membrane and nuclear melatonin signalling and provide new data on the hormonal regulation of telomerase function.",
keywords = "Breast cancer, Melatonin, Telomerase, Telomerase reverse transcriptase (TERT), Telomerase RNA (TR), Tumorogenesis",
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T1 - RNA expression of human telomerase subunits TR and TERT is differentially affected by melatonin receptor agonists in the MCF-7 tumor cell line

AU - Leon-Blanco, Mercedes M.

AU - Guerrero, Juan M.

AU - Reiter, Russel J

AU - Pozo, David

PY - 2004/12/8

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N2 - The RNA expression levels of human catalytic subunit (TERT) and the RNA subunit (TR) of telomerase were analysed after treatment with the agonists of the membrane receptor (S 20098) and the nuclear receptor (CGP 52608) for melatonin in the MCF-7 human breast tumor cell line. Neither membrane nor nuclear signalling affected the RNA steady-state levels of the TR subunit of telomerase. On the contrary, we observed a significant decreased in the RNA levels of TERT after treatment with CGP 52608 while S 20098 produced a significant increase in the RNA levels of TERT. These results support a cross-talk between membrane and nuclear melatonin signalling and provide new data on the hormonal regulation of telomerase function.

AB - The RNA expression levels of human catalytic subunit (TERT) and the RNA subunit (TR) of telomerase were analysed after treatment with the agonists of the membrane receptor (S 20098) and the nuclear receptor (CGP 52608) for melatonin in the MCF-7 human breast tumor cell line. Neither membrane nor nuclear signalling affected the RNA steady-state levels of the TR subunit of telomerase. On the contrary, we observed a significant decreased in the RNA levels of TERT after treatment with CGP 52608 while S 20098 produced a significant increase in the RNA levels of TERT. These results support a cross-talk between membrane and nuclear melatonin signalling and provide new data on the hormonal regulation of telomerase function.

KW - Breast cancer

KW - Melatonin

KW - Telomerase

KW - Telomerase reverse transcriptase (TERT)

KW - Telomerase RNA (TR)

KW - Tumorogenesis

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