RNA binding protein Sex-lethal (Sxl) and control of Drosophila sex determination and dosage compensation

Luiz O.F. Penalva, Lucas Sánchez

Research output: Contribution to journalReview articlepeer-review

112 Scopus citations

Abstract

In the past two decades, scientists have elucidated the molecular mechanisms behind Drosophila sex determination and dosage compensation. These two processes are controlled essentially by two different sets of genes, which have in common a master regulatory gene, Sex-lethal (Sxl). Sxl encodes one of the best-characterized members of the family of RNA binding proteins. The analysis of different mechanisms involved in the regulation of the three identified Sxl target genes (Sex-lethal itself, transformer, and male specific lethal-2) has contributed to a better understanding of translation repression, as well as constitutive and alternative splicing. Studies using the Drosophila system have identified the features of the protein that contribute to its target specificity and regulatory functions. In this article, we review the existing data concerning Sxl protein, its biological functions, and the regulation of its target genes.

Original languageEnglish (US)
Pages (from-to)343-359
Number of pages17
JournalMicrobiology and Molecular Biology Reviews
Volume67
Issue number3
DOIs
StatePublished - Sep 2003

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology
  • Infectious Diseases

Fingerprint Dive into the research topics of 'RNA binding protein Sex-lethal (Sxl) and control of Drosophila sex determination and dosage compensation'. Together they form a unique fingerprint.

Cite this