RK2, a glial-specific homeodomain protein required for embryonic nerve cord condensation and viability in Drosophila

Gerard Campbell, Harald Göring, Tina Lin, Eric Spana, Siv Andersson, Chris Q. Doe, Andrew Tomlinson

    Research output: Contribution to journalArticlepeer-review

    228 Scopus citations

    Abstract

    We report the identification of RK2, a glial-specific homeodomain protein. RK2 is localized to the nucleus of virtually all embryonic and imaginal glial cells, with the exception of midline glia. Embryos mutant for the gene encoding RK2 are embryonic lethal but normal for early gliogenesis (birth, initial divisions and migration of glia) and axonogenesis (neuronal pathfinding and fasciculation). However, later in development, there are significantly fewer longitudinal glia that are spatially disorganized; in addition, there is a slight disorganization of axon fascicles and a defective nerve cord condensation. This suggests that RK2 is not required for early glial determination, but rather for aspects of glial differentiation or function that are required for embryonic viability.

    Original languageEnglish (US)
    Pages (from-to)2957-2966
    Number of pages10
    JournalDevelopment
    Volume120
    Issue number10
    StatePublished - Oct 1994

    Keywords

    • Drosophila
    • Glia
    • Homeodomain protein
    • Nerve cord
    • RK2
    • Viablility

    ASJC Scopus subject areas

    • Molecular Biology
    • Developmental Biology

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