Abstract
Antibody-mediated anti-glomerular basement membrane (anti-GBM) disease occurs rarely in the presence of another B-cell disorder, membranous nephropathy. The coexistence of these two autoimmune disorders would be anticipated to require differing, specific therapies targeted to each disease process. We describe a case of concomitant membranous nephropathy and anti-GBM disease in which conventional therapy, including steroids, plasmapheresis and cyclophosphamide, failed to attenuate the anti-GBM disease, yet responded to an alternative treatment of rituximab. This B-cell directed, monoclonal, chimeric antibody treatment substantially reduced anti-GBM antibody titers and led to discontinuation of plasmapheresis, while maintaining the remission of membranous nephropathy and anti-GBM disease.
Original language | English (US) |
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Pages (from-to) | 53-56 |
Number of pages | 4 |
Journal | Clinical Kidney Journal |
Volume | 7 |
Issue number | 1 |
DOIs | |
State | Published - Feb 2014 |
Keywords
- Goodpasture syndrome
- anti CD-20
- anti-GBM disease
- membranous nephropathy, rituximab
ASJC Scopus subject areas
- Nephrology
- Transplantation