Risperidone vs. haloperidol on reaction time, manual dexterity, and motor learning in treatment-resistant schizophrenia patients

Robert S. Kern, Michael F. Green, Barringer D. Marshall, William C. Wirshing, Donna Wirshing, Susan McGurk, Stephen R. Marder, Jim Mintz

Research output: Contribution to journalArticlepeer-review

80 Scopus citations

Abstract

Background: The present study compared the effects of risperidone vs. haloperidol on reaction time, manual dexterity, and two types of motor learning in a sample of treatment-resistant schizophrenia patients. Methods: Fifty-six DSM-III-R diagnosed schizophrenia inpatients participated in a randomized, double-blind comparison of risperidone vs. haloperidol. Measures of reaction time, manual dexterity, motor sequence learning, and gross motor learning were administered at baseline, after 4 weeks of fixed-dose medication, and after 4 weeks of flexible-dose medication. Results: The results indicated that patients receiving risperidone showed greater improvement in reaction time and manual dexterity than patients receiving haloperidol. After covarying symptom changes and movement disorder : ratings, the results remained significant. The two treatment groups did not differ on either measure of motor: learning. Conclusions: The differences in performance in reaction time and manual dexterity may be due to a specific beneficial effect of risperidone, as opposed to a general reduction in extrapyramidal symptom liability, compared to haloperidol.

Original languageEnglish (US)
Pages (from-to)726-732
Number of pages7
JournalBiological Psychiatry
Volume44
Issue number8
DOIs
StatePublished - Oct 15 1998
Externally publishedYes

Keywords

  • Haloperidol
  • Manual dexterity
  • Psychomotor speed
  • Reaction time
  • Risperidone
  • Schizophrenia

ASJC Scopus subject areas

  • Biological Psychiatry

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