Risk of oophorectomy after hysterectomy

Elizabeth C Evans, Emanuel C. Trabuco, Adil E. Bharucha, Amy L. Weaver, Cathy D. Schleck, L. Joseph Melton, John B. Gebhart

Research output: Contribution to journalArticle

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Abstract

OBJECTIVE: To compare the risk of subsequent oophorectomy among women who underwent hysterectomy for benign indications and those who did not. METHODS: Using Rochester Epidemiology Project resources, we compared the risk of oophorectomy through December 31, 2008, among 4,931 women in Olmsted County, Minnesota, who underwent ovary-sparing hysterectomy for benign indications (case group) between 1965 and 2002, with 4,931 age-matched women who did not undergo hysterectomy (referent group). The cumulative incidence of subsequent oophorectomy was estimated by the Kaplan-Meier method, and comparisons were evaluated by Cox proportional hazard models using age as the time scale to allow for complete age adjustment. RESULTS: The median follow-up times for case group and referent group participants were 19.6 and 19.4 years, respectively. At 10, 20, and 30 years after hysterectomy, the respective cumulative incidences of subsequent oophorectomy were 3.5%, 6.2%, and 9.2% among case group participants and 1.9%, 4.8%, and 7.3% among referent group participants. The overall risk of subsequent oophorectomy among case group participants was significantly higher than among referent group participants (hazard ratio [HR] 1.20, 95% confidence interval [CI] 1.02-1.42; P=.03). Furthermore, among case group participants, the risk of subsequent oophorectomy was significantly higher (HR 2.15, 95% CI 1.51-3.07; P<.001) in women who had both ovaries preserved compared with those who initially had one ovary preserved. CONCLUSION: The incidence of oophorectomy after hysterectomy is only 9.2% at 30-year follow-up and is only 1.9 percentage points higher than the incidence of oophorectomy in referent women with intact reproductive organs.

Original languageEnglish (US)
Pages (from-to)1069-1074
Number of pages6
JournalObstetrics and Gynecology
Volume121
Issue number5
DOIs
StatePublished - May 2013
Externally publishedYes

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Ovariectomy
Hysterectomy
Ovary
Incidence
Confidence Intervals
Proportional Hazards Models
Epidemiology

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Evans, E. C., Trabuco, E. C., Bharucha, A. E., Weaver, A. L., Schleck, C. D., Melton, L. J., & Gebhart, J. B. (2013). Risk of oophorectomy after hysterectomy. Obstetrics and Gynecology, 121(5), 1069-1074. https://doi.org/10.1097/AOG.0b013e31828e89df

Risk of oophorectomy after hysterectomy. / Evans, Elizabeth C; Trabuco, Emanuel C.; Bharucha, Adil E.; Weaver, Amy L.; Schleck, Cathy D.; Melton, L. Joseph; Gebhart, John B.

In: Obstetrics and Gynecology, Vol. 121, No. 5, 05.2013, p. 1069-1074.

Research output: Contribution to journalArticle

Evans, EC, Trabuco, EC, Bharucha, AE, Weaver, AL, Schleck, CD, Melton, LJ & Gebhart, JB 2013, 'Risk of oophorectomy after hysterectomy', Obstetrics and Gynecology, vol. 121, no. 5, pp. 1069-1074. https://doi.org/10.1097/AOG.0b013e31828e89df
Evans EC, Trabuco EC, Bharucha AE, Weaver AL, Schleck CD, Melton LJ et al. Risk of oophorectomy after hysterectomy. Obstetrics and Gynecology. 2013 May;121(5):1069-1074. https://doi.org/10.1097/AOG.0b013e31828e89df
Evans, Elizabeth C ; Trabuco, Emanuel C. ; Bharucha, Adil E. ; Weaver, Amy L. ; Schleck, Cathy D. ; Melton, L. Joseph ; Gebhart, John B. / Risk of oophorectomy after hysterectomy. In: Obstetrics and Gynecology. 2013 ; Vol. 121, No. 5. pp. 1069-1074.
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abstract = "OBJECTIVE: To compare the risk of subsequent oophorectomy among women who underwent hysterectomy for benign indications and those who did not. METHODS: Using Rochester Epidemiology Project resources, we compared the risk of oophorectomy through December 31, 2008, among 4,931 women in Olmsted County, Minnesota, who underwent ovary-sparing hysterectomy for benign indications (case group) between 1965 and 2002, with 4,931 age-matched women who did not undergo hysterectomy (referent group). The cumulative incidence of subsequent oophorectomy was estimated by the Kaplan-Meier method, and comparisons were evaluated by Cox proportional hazard models using age as the time scale to allow for complete age adjustment. RESULTS: The median follow-up times for case group and referent group participants were 19.6 and 19.4 years, respectively. At 10, 20, and 30 years after hysterectomy, the respective cumulative incidences of subsequent oophorectomy were 3.5{\%}, 6.2{\%}, and 9.2{\%} among case group participants and 1.9{\%}, 4.8{\%}, and 7.3{\%} among referent group participants. The overall risk of subsequent oophorectomy among case group participants was significantly higher than among referent group participants (hazard ratio [HR] 1.20, 95{\%} confidence interval [CI] 1.02-1.42; P=.03). Furthermore, among case group participants, the risk of subsequent oophorectomy was significantly higher (HR 2.15, 95{\%} CI 1.51-3.07; P<.001) in women who had both ovaries preserved compared with those who initially had one ovary preserved. CONCLUSION: The incidence of oophorectomy after hysterectomy is only 9.2{\%} at 30-year follow-up and is only 1.9 percentage points higher than the incidence of oophorectomy in referent women with intact reproductive organs.",
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AU - Evans, Elizabeth C

AU - Trabuco, Emanuel C.

AU - Bharucha, Adil E.

AU - Weaver, Amy L.

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AU - Melton, L. Joseph

AU - Gebhart, John B.

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N2 - OBJECTIVE: To compare the risk of subsequent oophorectomy among women who underwent hysterectomy for benign indications and those who did not. METHODS: Using Rochester Epidemiology Project resources, we compared the risk of oophorectomy through December 31, 2008, among 4,931 women in Olmsted County, Minnesota, who underwent ovary-sparing hysterectomy for benign indications (case group) between 1965 and 2002, with 4,931 age-matched women who did not undergo hysterectomy (referent group). The cumulative incidence of subsequent oophorectomy was estimated by the Kaplan-Meier method, and comparisons were evaluated by Cox proportional hazard models using age as the time scale to allow for complete age adjustment. RESULTS: The median follow-up times for case group and referent group participants were 19.6 and 19.4 years, respectively. At 10, 20, and 30 years after hysterectomy, the respective cumulative incidences of subsequent oophorectomy were 3.5%, 6.2%, and 9.2% among case group participants and 1.9%, 4.8%, and 7.3% among referent group participants. The overall risk of subsequent oophorectomy among case group participants was significantly higher than among referent group participants (hazard ratio [HR] 1.20, 95% confidence interval [CI] 1.02-1.42; P=.03). Furthermore, among case group participants, the risk of subsequent oophorectomy was significantly higher (HR 2.15, 95% CI 1.51-3.07; P<.001) in women who had both ovaries preserved compared with those who initially had one ovary preserved. CONCLUSION: The incidence of oophorectomy after hysterectomy is only 9.2% at 30-year follow-up and is only 1.9 percentage points higher than the incidence of oophorectomy in referent women with intact reproductive organs.

AB - OBJECTIVE: To compare the risk of subsequent oophorectomy among women who underwent hysterectomy for benign indications and those who did not. METHODS: Using Rochester Epidemiology Project resources, we compared the risk of oophorectomy through December 31, 2008, among 4,931 women in Olmsted County, Minnesota, who underwent ovary-sparing hysterectomy for benign indications (case group) between 1965 and 2002, with 4,931 age-matched women who did not undergo hysterectomy (referent group). The cumulative incidence of subsequent oophorectomy was estimated by the Kaplan-Meier method, and comparisons were evaluated by Cox proportional hazard models using age as the time scale to allow for complete age adjustment. RESULTS: The median follow-up times for case group and referent group participants were 19.6 and 19.4 years, respectively. At 10, 20, and 30 years after hysterectomy, the respective cumulative incidences of subsequent oophorectomy were 3.5%, 6.2%, and 9.2% among case group participants and 1.9%, 4.8%, and 7.3% among referent group participants. The overall risk of subsequent oophorectomy among case group participants was significantly higher than among referent group participants (hazard ratio [HR] 1.20, 95% confidence interval [CI] 1.02-1.42; P=.03). Furthermore, among case group participants, the risk of subsequent oophorectomy was significantly higher (HR 2.15, 95% CI 1.51-3.07; P<.001) in women who had both ovaries preserved compared with those who initially had one ovary preserved. CONCLUSION: The incidence of oophorectomy after hysterectomy is only 9.2% at 30-year follow-up and is only 1.9 percentage points higher than the incidence of oophorectomy in referent women with intact reproductive organs.

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