Risk of nosocomial infection with human T-cell lymphotropic virus type III/lymphadenopathy-associated virus in a large cohort of intensively exposed health care workers

D. K. Henderson, A. J. Saah, B. J. Zak, R. A. Kaslow, H. C. Lane, T. Folks, W. C. Blackwelder, J. Schmitt, D. J. LaCamera, H. Masur

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    127 Scopus citations

    Abstract

    To assess the risk of nosocomial transmission of human T-cell lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV), we prospectively evaluated a cohort of 531 health care workers. One hundred fifty of these employees reported percutaneous or mucous membrane exposures to blood or body fluids from a patient with the acquired immunodeficiency syndrome (AIDS) during the treatment of 238 such patients since 1981. None of these 150 employees had serologic evidence of HTLV-III/LAV infection on follow-up from 6 to 46 months after exposure. Of the 150, 46 were studied immunologically and 29 had lymphocytes cultured for HTLV-III/LAV. Results of all studies were normal. Of the 531 employees, 3 (0.56%) had serologic evidence of HTLV-III/LAV infection. All were seropositive at the time of study entry; none reported adverse nosocomial exposures. All acknowledged membership in one or more established risk groups for AIDS. This study provides strong evidence that the risk of nosocomial transmission of HTLV-III/LAV is extremely low.

    Original languageEnglish (US)
    Pages (from-to)644-647
    Number of pages4
    JournalAnnals of internal medicine
    Volume104
    Issue number5
    DOIs
    StatePublished - Jan 1 1986

    ASJC Scopus subject areas

    • Internal Medicine

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