TY - JOUR
T1 - Risk of developing diabetes and cardiovascular disease in metabolically unhealthy normal-weight and metabolically healthy obese individuals
AU - Aung, Ko Ko
AU - Lorenzo, Carlos
AU - Hinojosa, Marco A.
AU - Haffner, Steven M.
PY - 2014/2
Y1 - 2014/2
N2 - Context: The risk of cardiovascular disease (CVD) and type 2 diabetes mellitus (DM) associated with obesity appears to be influenced by the coexistence of other metabolic abnormalities. Objective:Weexamined the risk of developing CVD andDMin metabolically healthy obese (MHO) and metabolically unhealthy normal weight (MUH-NW) individuals. Design and Setting: We analyzed prospective data of the San Antonio Heart Study, a populationbased study among Mexican Americans and non-Hispanic whites (median follow-up, 7.4 y). Participants: IncidentDMandCVDwere assessed in 2814 and 3700 participants aged 25 to 64 years, respectively. Main Measures:MHOwas defined as obesity (body mass index ≥30 kg/m2) with no more than one metabolic abnormality, andMUH-NWwas defined as body mass index <25 kg/m2 with two or more abnormalities. Results: In logistic regression models, BMI was associated with incident DM after controlling for demographics, family history of DM, and fasting glucose (odds ratio × 1 SD, 1.7 [95% CI, 1.5-2.0]). Both MUH-NW and MHO individuals had an increased DM risk (2.5 [1.1-5.6] and 3.9 [2.0 -7.4], respectively). Similarly, BMI was related to incident CVD after adjusting for demographics and Framingham risk score (1.3 [1.1-1.6]). Incident CVD was also increased in MUH-NW and MHO individuals (2.9 [1.3- 6.4] and 3.9 [1.9 -7.8], respectively). Results were consistent across gender and ethnic categories. Conclusion: The risk of developingDMandCVDis increased inMUH- NWandMHOindividuals. Screening for obesity and other metabolic abnormalities should be routinely performed in clinical practice to institute appropriate preventive measures.
AB - Context: The risk of cardiovascular disease (CVD) and type 2 diabetes mellitus (DM) associated with obesity appears to be influenced by the coexistence of other metabolic abnormalities. Objective:Weexamined the risk of developing CVD andDMin metabolically healthy obese (MHO) and metabolically unhealthy normal weight (MUH-NW) individuals. Design and Setting: We analyzed prospective data of the San Antonio Heart Study, a populationbased study among Mexican Americans and non-Hispanic whites (median follow-up, 7.4 y). Participants: IncidentDMandCVDwere assessed in 2814 and 3700 participants aged 25 to 64 years, respectively. Main Measures:MHOwas defined as obesity (body mass index ≥30 kg/m2) with no more than one metabolic abnormality, andMUH-NWwas defined as body mass index <25 kg/m2 with two or more abnormalities. Results: In logistic regression models, BMI was associated with incident DM after controlling for demographics, family history of DM, and fasting glucose (odds ratio × 1 SD, 1.7 [95% CI, 1.5-2.0]). Both MUH-NW and MHO individuals had an increased DM risk (2.5 [1.1-5.6] and 3.9 [2.0 -7.4], respectively). Similarly, BMI was related to incident CVD after adjusting for demographics and Framingham risk score (1.3 [1.1-1.6]). Incident CVD was also increased in MUH-NW and MHO individuals (2.9 [1.3- 6.4] and 3.9 [1.9 -7.8], respectively). Results were consistent across gender and ethnic categories. Conclusion: The risk of developingDMandCVDis increased inMUH- NWandMHOindividuals. Screening for obesity and other metabolic abnormalities should be routinely performed in clinical practice to institute appropriate preventive measures.
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U2 - 10.1210/jc.2013-2832
DO - 10.1210/jc.2013-2832
M3 - Article
C2 - 24257907
AN - SCOPUS:84896714517
SN - 0021-972X
VL - 99
SP - 462
EP - 468
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
IS - 2
ER -