Risk factors influencing antibody responses to kaposi's sarcoma-associated herpesvirus latent and lytic antigens in patients under antiretroviral therapy

Moraima Guadalupe, Brad H. Pollock, Steven Westbrook, Spencer Redding, Delia Bullock, Gregory Anstead, Brian K. Agan, Vincent C. Marconi, Sharon Barbieri, Vidya Sankar, Jennifer Rebeles, Yvette Flahive, John Schoolfield, Linding Wang, Xiufen Lei, Dorothy Dow, Chih Ko Yeh, Howard Dang, Anthony J. Infante, Shou Jiang Gao

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Background: Kaposi's sarcoma-associated herpesvirus (KSHV) seropositivity and lytic antibody titer are predictors for Kaposi's sarcoma. Methods: We examined demographic, viral, and immunologic factors that influence KSHV latent and lytic antibodies in HIV-infected patients. Results: Detection rate of KSHV latent but not lytic antibodies was lower in patients with CD4 cells/mm less than 200 than greater than 200 (odds ratio [OR], 0.26; 95% confidence interval [CI], 0.11-0.61) and CD8 cells/mm less than 400 than greater than 400 (OR, 0.26; 95% CI, 0.07-0.67). Overall seropositivity rate was higher in patients with CD4 cells/mm less than 200 than greater than 200 (OR, 2.34; 95% CI, 1.37-4.02) and HIV copies/mL greater than 400 than less than 400 (OR, 1.70; 95% CI, 1.09-2.65). Lytic antibody level was inversely correlated with CD4 count (P < 0.001). Lytic seropositivity (OR, 2.47; 95% CI, 1.35-4.50) and antibody level (adjusted difference mean optical density, 0.324; 95% CI, 0.16-0.46) were higher in patients with HIV infection greater than 15 than less than 15 years. Hispanics had higher lytic seropositivity rate (OR, 1.71; 95% CI, 1.07-2.73) and antibody level (adjusted difference mean optical density, 0.111; 95% CI, 0.03-0.18) than non-Hispanics. Conclusions: Lower CD4 and CD8 counts impair antibody response to KSHV latent antigens. Immune deterioration, long-term HIV infection, and Hispanic status are risk factors for Kaposi's sarcoma predictors.

Original languageEnglish (US)
Pages (from-to)83-90
Number of pages8
JournalJournal of Acquired Immune Deficiency Syndromes
Volume56
Issue number1
DOIs
StatePublished - Jan 1 2011

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

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