Risk factors for mortality after respiratory syncytial virus lower respiratory tract infection in adults with hematologic malignancies

Erik Vakil, Ajay Sheshadri, Saadia A. Faiz, Dimpy P. Shah, Yayuan Zhu, Liang Li, Joumana Kmeid, Jacques Azzi, Amulya Balagani, Lara Bashoura, Ella Ariza-Heredia, Roy F. Chemaly

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Background: Respiratory syncytial virus (RSV) lower respiratory tract infection (LRTI) is associated with high mortality in patients with hematologic malignancies (HM). We sought to determine whether allogeneic hematopoietic cell transplant (allo-HCT) recipients would be at higher risk for 60-day mortality. Methods: We examined a retrospective cohort of adults with HM with or without HCT treated for RSV LRTI (n = 154) at our institution from 1996-2013. We defined possible RSV LRTI as RSV detected only in the upper respiratory tract with new radiologic infiltrates and proven RSV LRTI as RSV detected in BAL fluid with new radiologic infiltrates. Immunodeficiency Scoring Index (ISI) and Severe Immunodeficiency (SID) criteria were calculated for HCT recipients. Multivariable logistic regression analyses were performed to identify independent risk factors associated with 60-day all-cause mortality. Results: Mortality was high in HM patients (25%), but there was no difference between those without HCT, autologous or allo-HCT recipients in logistic regression models. Separate multivariate models showed that at RSV diagnosis, neutropenia (OR 8.3, 95% CI 2.8-24.2, P = 0.005) and lymphopenia (OR 3.7, 95% CI 1.7-8.2, P = 0.001) were associated with 60-day mortality. Proven LRTI was associated with higher 60-day mortality (neutropenia model: OR 4.7, 95%CI 1.7-13.5; lymphopenia model: OR 3.3, 95% CI 1.2-8.8), and higher ICU admission. In HCT recipients, high ISI and very severe immunodeficiency by SID criteria were associated with higher 60-day all-cause mortality. Conclusions: Mortality is similarly high among HM patients without HCT and HCT recipients. High-grade immunodeficiency and detection of RSV from BAL fluid are associated with higher 60-day mortality.

Original languageEnglish (US)
Article numbere12994
JournalTransplant Infectious Disease
Issue number6
StatePublished - Dec 2018


  • hematologic malignancy
  • hematopoietic cell transplantation
  • lower respiratory tract infection
  • mortality
  • respiratory syncytial virus

ASJC Scopus subject areas

  • Infectious Diseases
  • Transplantation


Dive into the research topics of 'Risk factors for mortality after respiratory syncytial virus lower respiratory tract infection in adults with hematologic malignancies'. Together they form a unique fingerprint.

Cite this