TY - JOUR
T1 - Risk factors for COPD exacerbations in inhaled medication users
T2 - The COPDGene study biannual longitudinal follow-up prospective cohort
AU - The COPDGene Investigators
AU - Busch, Robert
AU - Han, Meilan K.
AU - Bowler, Russell P.
AU - Dransfield, Mark T.
AU - Wells, J. Michael
AU - Regan, Elizabeth A.
AU - Hersh, Craig P.
AU - Crapo, James
AU - Silverman, Edwin
AU - Make, Barry
AU - Beaty, Terri
AU - Laird, Nan
AU - Lange, Christoph
AU - Cho, Michael
AU - Santorico, Stephanie
AU - Castaldi, Peter
AU - McDonald, Merry Lynn
AU - Wan, Emily
AU - Hardin, Megan
AU - Hetmanski, Jacqueline
AU - Parker, Margaret
AU - Hobbs, Brian
AU - El-Boueiz, Adel
AU - Qiao, Dandi
AU - Halper-Stromberg, Eitan
AU - Begum, Ferdouse
AU - Won, Sungho
AU - Coxson, Harvey O.
AU - Hoffman, Eric A.
AU - Humphries, Stephen
AU - Judy, Philip F.
AU - Newell, John D.
AU - Ross, James C.
AU - Estepar, Raul San Jose
AU - Stoel, Berend C.
AU - Tschirren, Juerg
AU - van Rikxoort, Eva
AU - van Ginneken, Bram
AU - Al Qaisi, Mustafa
AU - Gray, Teresa
AU - Kluiber, Alex
AU - Mann, Tanya
AU - Sieren, Jered
AU - Stinson, Douglas
AU - Schroeder, Joyce
AU - Van Beek, Edwin
AU - Jensen, Robert
AU - Anzueto, Antonio
AU - Adams, Sandra
AU - Maselli-Caceres, Diego
N1 - Publisher Copyright:
© 2016 Busch et al.
PY - 2016/2/10
Y1 - 2016/2/10
N2 - Background: Despite inhaled medications that decrease exacerbation risk, some COPD patients experience frequent exacerbations. We determined prospective risk factors for exacerbations among subjects in the COPDGene Study taking inhaled medications. Methods: 2113 COPD subjects were categorized into four medication use patterns: triple therapy with tiotropium (TIO) plus long-acting beta-agonist/inhaled-corticosteroid (ICS ± LABA), tiotropium alone, ICS ± LABA, and short-acting bronchodilators. Self-reported exacerbations were recorded in telephone and web-based longitudinal follow-up surveys. Associations with exacerbations were determined within each medication group using four separate logistic regression models. A head-to-head analysis compared exacerbation risk among subjects using tiotropium vs. ICS ± LABA. Results: In separate logistic regression models, the presence of gastroesophageal reflux, female gender, and higher scores on the St. George's Respiratory Questionnaire were significant predictors of exacerbator status within multiple medication groups (reflux: OR 1.62-2.75; female gender: OR 1.53 - OR 1.90; SGRQ: OR 1.02-1.03). Subjects taking either ICS ± LABA or tiotropium had similar baseline characteristics, allowing comparison between these two groups. In the head-to-head comparison, tiotropium users showed a trend towards lower rates of exacerbations (OR = 0.69 [95 % CI 0.45, 1.06], p = 0.09) compared with ICS ± LABA users, especially in subjects without comorbid asthma (OR = 0.56 [95 % CI 0.31, 1.00], p = 0.05). Conclusions: Each common COPD medication usage group showed unique risk factor patterns associated with increased risk of exacerbations, which may help clinicians identify subjects at risk. Compared to similar subjects using ICS ± LABA, those taking tiotropium showed a trend towards reduced exacerbation risk, especially in subjects without asthma. Trial registration: ClinicalTrials.gov NCT00608764 , first received 1/28/2008.
AB - Background: Despite inhaled medications that decrease exacerbation risk, some COPD patients experience frequent exacerbations. We determined prospective risk factors for exacerbations among subjects in the COPDGene Study taking inhaled medications. Methods: 2113 COPD subjects were categorized into four medication use patterns: triple therapy with tiotropium (TIO) plus long-acting beta-agonist/inhaled-corticosteroid (ICS ± LABA), tiotropium alone, ICS ± LABA, and short-acting bronchodilators. Self-reported exacerbations were recorded in telephone and web-based longitudinal follow-up surveys. Associations with exacerbations were determined within each medication group using four separate logistic regression models. A head-to-head analysis compared exacerbation risk among subjects using tiotropium vs. ICS ± LABA. Results: In separate logistic regression models, the presence of gastroesophageal reflux, female gender, and higher scores on the St. George's Respiratory Questionnaire were significant predictors of exacerbator status within multiple medication groups (reflux: OR 1.62-2.75; female gender: OR 1.53 - OR 1.90; SGRQ: OR 1.02-1.03). Subjects taking either ICS ± LABA or tiotropium had similar baseline characteristics, allowing comparison between these two groups. In the head-to-head comparison, tiotropium users showed a trend towards lower rates of exacerbations (OR = 0.69 [95 % CI 0.45, 1.06], p = 0.09) compared with ICS ± LABA users, especially in subjects without comorbid asthma (OR = 0.56 [95 % CI 0.31, 1.00], p = 0.05). Conclusions: Each common COPD medication usage group showed unique risk factor patterns associated with increased risk of exacerbations, which may help clinicians identify subjects at risk. Compared to similar subjects using ICS ± LABA, those taking tiotropium showed a trend towards reduced exacerbation risk, especially in subjects without asthma. Trial registration: ClinicalTrials.gov NCT00608764 , first received 1/28/2008.
KW - Adrenergic beta-agonists
KW - COPD exacerbation
KW - Chronic obstructive pulmonary disease
KW - Inhaled corticosteroid
KW - Inhaled medications
KW - Long-acting beta-agonist
KW - Prospective cohort study
KW - Tiotropium
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U2 - 10.1186/s12890-016-0191-7
DO - 10.1186/s12890-016-0191-7
M3 - Article
C2 - 26861867
AN - SCOPUS:84957553849
SN - 1471-2466
VL - 16
JO - BMC Pulmonary Medicine
JF - BMC Pulmonary Medicine
IS - 1
M1 - 28
ER -