Riccati-regularized precision matrices for neuroimaging

Nicolas Honnorat, Christos Davatzikos

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations


The introduction of graph theory in neuroimaging has provided invaluable tools for the study of brain connectivity. These methods require the definition of a graph, which is typically derived by estimating the effective connectivity between brain regions through the optimization of an ill-posed inverse problem. Considerable efforts have been devoted to the development of methods extracting sparse connectivity graphs. The present paper aims at highlighting the benefits of an alternative approach.We investigate low-rank L2 regularized matrices recently introduced under the denomination of Riccati regularized precision matrices. We demonstrate their benefits for the analysis of cortical thickness map and the extraction of functional biomarkers from resting state fMRI scans. In addition, we explain how speed and result quality can be further improved with random projections. The promising results obtained using the Human Connectome Project dataset, as well as, the numerous possible extensions and applications suggest that Riccati precision matrices might usefully complement current sparse approaches.

Original languageEnglish (US)
Title of host publicationInformation Processing in Medical Imaging - 25th International Conference, IPMI 2017, Proceedings
EditorsHongtu Zhu, Marc Niethammer, Martin Styner, Hongtu Zhu, Dinggang Shen, Pew-Thian Yap, Stephen Aylward, Ipek Oguz
PublisherSpringer Verlag
Number of pages12
ISBN (Print)9783319590493
StatePublished - 2017
Externally publishedYes
Event25th International Conference on Information Processing in Medical Imaging, IPMI 2017 - Boone, United States
Duration: Jun 25 2017Jun 30 2017

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume10265 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349


Conference25th International Conference on Information Processing in Medical Imaging, IPMI 2017
Country/TerritoryUnited States


  • Precision
  • Sparse inverse covariance
  • rs-fMRI

ASJC Scopus subject areas

  • Theoretical Computer Science
  • General Computer Science


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