Ribavirin is an inhibitor of human immunodeficiency virus reverse transcriptase

R. Fernandez-Larsson, J. L. Patterson

    Research output: Contribution to journalArticlepeer-review

    44 Scopus citations

    Abstract

    Ribavirin inhibits the human immunodeficiency virus reverse transcriptase in an in vitro reaction. Ribavirin-5'-diphosphate was close to 40% more inhibitory than ribavirin-5'-triphosphate. Unphosphorylated ribavirin had a reduced, but detectable, effect as an inhibitor, compared with the phosphorylated forms. The compounds seem to have a direct effect on the viral polymerase, and no chain termination was observed in the presence of ribavirin-5'-triphosphate. Combination of any of the ribavirin derivatives tested with 3'-azido-3'-deoxythymidine (zidovudine)-5'-triphosphate resulted in an increase of its anti-human immunodeficiency virus reverse transcriptase activity in the in vitro assay.

    Original languageEnglish (US)
    Pages (from-to)766-770
    Number of pages5
    JournalMolecular pharmacology
    Volume38
    Issue number6
    StatePublished - 1990

    ASJC Scopus subject areas

    • Molecular Medicine
    • Pharmacology

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