Rhythms in immunoreactive melatonin in the retina and harderian gland of rats: Persistence after pinealectomy

Russel J. Reiter; Bruce A. Richardson; Susan A. Matthews; Shelly J. Lane; Bonnie N. Ferguson

doi:10.1016/0024-3205(83)90192-3

Rhythms in immunoreactive melatonin in the retina and harderian gland of rats: Persistence after pinealectomy

Russel J. Reiter, Bruce A. Richardson, Susan A. Matthews, Shelly J. Lane, Bonnie N. Ferguson

Department of Cell Systems & Anatomy

Research output: Contribution to journal › Article › peer-review

152 Scopus citations

Abstract

Immunoreactive melatonin levels were measured in the retina and Harderian gland of adult male rats throughout a 24 hour period. The animals were maintained under a light:dark cycle of 14:10 (lights on at 0600h). In intact animals, immunoreactive melatonin values in both organs exhibited a 24h rhythm with peak levels being measured at 0800h, 2 hours after lights on. Pinealectomy significantly increased peak levels at 0800h in both the retina and the Harderian gland. Gonadectomy abolished the peak retinal melatonin levels at 0800h. Likewise, continual light exposure for 1 week depressed the melatonin peak in the retina but not in the Harderian gland.

Original language	English (US)
Pages (from-to)	1229-1236
Number of pages	8
Journal	Life Sciences
Volume	32
Issue number	11
DOIs	https://doi.org/10.1016/0024-3205(83)90192-3
State	Published - Mar 14 1983

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Pharmacology, Toxicology and Pharmaceutics

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title = "Rhythms in immunoreactive melatonin in the retina and harderian gland of rats: Persistence after pinealectomy",

abstract = "Immunoreactive melatonin levels were measured in the retina and Harderian gland of adult male rats throughout a 24 hour period. The animals were maintained under a light:dark cycle of 14:10 (lights on at 0600h). In intact animals, immunoreactive melatonin values in both organs exhibited a 24h rhythm with peak levels being measured at 0800h, 2 hours after lights on. Pinealectomy significantly increased peak levels at 0800h in both the retina and the Harderian gland. Gonadectomy abolished the peak retinal melatonin levels at 0800h. Likewise, continual light exposure for 1 week depressed the melatonin peak in the retina but not in the Harderian gland.",

author = "Reiter, {Russel J.} and Richardson, {Bruce A.} and Matthews, {Susan A.} and Lane, {Shelly J.} and Ferguson, {Bonnie N.}",

note = "Funding Information: Supported by NSF grant no. PCM 8003441. During the course of the study BAR was an NIH postdoctoral fellow (I F32 ND05900).",

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T1 - Rhythms in immunoreactive melatonin in the retina and harderian gland of rats

T2 - Persistence after pinealectomy

AU - Reiter, Russel J.

AU - Richardson, Bruce A.

AU - Matthews, Susan A.

AU - Lane, Shelly J.

AU - Ferguson, Bonnie N.

N1 - Funding Information: Supported by NSF grant no. PCM 8003441. During the course of the study BAR was an NIH postdoctoral fellow (I F32 ND05900).

PY - 1983/3/14

Y1 - 1983/3/14

N2 - Immunoreactive melatonin levels were measured in the retina and Harderian gland of adult male rats throughout a 24 hour period. The animals were maintained under a light:dark cycle of 14:10 (lights on at 0600h). In intact animals, immunoreactive melatonin values in both organs exhibited a 24h rhythm with peak levels being measured at 0800h, 2 hours after lights on. Pinealectomy significantly increased peak levels at 0800h in both the retina and the Harderian gland. Gonadectomy abolished the peak retinal melatonin levels at 0800h. Likewise, continual light exposure for 1 week depressed the melatonin peak in the retina but not in the Harderian gland.

AB - Immunoreactive melatonin levels were measured in the retina and Harderian gland of adult male rats throughout a 24 hour period. The animals were maintained under a light:dark cycle of 14:10 (lights on at 0600h). In intact animals, immunoreactive melatonin values in both organs exhibited a 24h rhythm with peak levels being measured at 0800h, 2 hours after lights on. Pinealectomy significantly increased peak levels at 0800h in both the retina and the Harderian gland. Gonadectomy abolished the peak retinal melatonin levels at 0800h. Likewise, continual light exposure for 1 week depressed the melatonin peak in the retina but not in the Harderian gland.

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Rhythms in immunoreactive melatonin in the retina and harderian gland of rats: Persistence after pinealectomy

Abstract

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