Rheumatic chorea

Luiz Paulo Bastos Vasconcelos; Marcelle Cristina Vasconcelos; Maria do Carmo Pereira Nunes; Antonio Lucio Teixeira

doi:10.1016/B978-0-323-85831-1.00018-8

Rheumatic chorea

Luiz Paulo Bastos Vasconcelos, Marcelle Cristina Vasconcelos, Maria do Carmo Pereira Nunes, Antonio Lucio Teixeira

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

Rheumatic chorea (RC), also known as Sydenham’s chorea, is a late manifestation of acute rheumatic fever (RF) and represents one of the main diagnostic criteria of the disease. RC is a well-recognized autoimmune movement disorder elicited by group A beta-hemolytic streptococcal (GABHS) pharyngitis. Clinically, RC is characterized by involuntary arrhythmic movements and cognitive and behavioral symptoms. RC supposedly results from basal ganglia dysfunction triggered by cross-reactive antibodies produced during GABHS infection. Recent studies have unveiled specific antibody targets in the basal ganglia possibly implicated in neural circuits dysfunction and, therefore, in the emergence of neurological symptoms. In this chapter, we summarize current evidence on clinical and pathophysiological aspects of RC.

Original language	English (US)
Title of host publication	Translational Autoimmunity
Subtitle of host publication	Volume 6: Advances in Autoimmune Rheumatic Diseases
Publisher	Elsevier
Pages	373-387
Number of pages	15
ISBN (Electronic)	9780323858311
ISBN (Print)	9780323984546
DOIs	https://doi.org/10.1016/B978-0-323-85831-1.00018-8
State	Published - Jan 1 2023
Externally published	Yes

Keywords

Autoimmune movement disorders
Neuropsychiatric manifestation
Rheumatic chorea
Rheumatic fever
Sydenham’s chorea

ASJC Scopus subject areas

General Medicine
General Immunology and Microbiology

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10.1016/B978-0-323-85831-1.00018-8

Cite this

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title = "Rheumatic chorea",

abstract = "Rheumatic chorea (RC), also known as Sydenham{\textquoteright}s chorea, is a late manifestation of acute rheumatic fever (RF) and represents one of the main diagnostic criteria of the disease. RC is a well-recognized autoimmune movement disorder elicited by group A beta-hemolytic streptococcal (GABHS) pharyngitis. Clinically, RC is characterized by involuntary arrhythmic movements and cognitive and behavioral symptoms. RC supposedly results from basal ganglia dysfunction triggered by cross-reactive antibodies produced during GABHS infection. Recent studies have unveiled specific antibody targets in the basal ganglia possibly implicated in neural circuits dysfunction and, therefore, in the emergence of neurological symptoms. In this chapter, we summarize current evidence on clinical and pathophysiological aspects of RC.",

keywords = "Autoimmune movement disorders, Neuropsychiatric manifestation, Rheumatic chorea, Rheumatic fever, Sydenham{\textquoteright}s chorea",

author = "Vasconcelos, {Luiz Paulo Bastos} and Vasconcelos, {Marcelle Cristina} and {do Carmo Pereira Nunes}, Maria and Teixeira, {Antonio Lucio}",

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doi = "10.1016/B978-0-323-85831-1.00018-8",

language = "English (US)",

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AU - Vasconcelos, Luiz Paulo Bastos

AU - Vasconcelos, Marcelle Cristina

AU - do Carmo Pereira Nunes, Maria

AU - Teixeira, Antonio Lucio

PY - 2023/1/1

Y1 - 2023/1/1

N2 - Rheumatic chorea (RC), also known as Sydenham’s chorea, is a late manifestation of acute rheumatic fever (RF) and represents one of the main diagnostic criteria of the disease. RC is a well-recognized autoimmune movement disorder elicited by group A beta-hemolytic streptococcal (GABHS) pharyngitis. Clinically, RC is characterized by involuntary arrhythmic movements and cognitive and behavioral symptoms. RC supposedly results from basal ganglia dysfunction triggered by cross-reactive antibodies produced during GABHS infection. Recent studies have unveiled specific antibody targets in the basal ganglia possibly implicated in neural circuits dysfunction and, therefore, in the emergence of neurological symptoms. In this chapter, we summarize current evidence on clinical and pathophysiological aspects of RC.

AB - Rheumatic chorea (RC), also known as Sydenham’s chorea, is a late manifestation of acute rheumatic fever (RF) and represents one of the main diagnostic criteria of the disease. RC is a well-recognized autoimmune movement disorder elicited by group A beta-hemolytic streptococcal (GABHS) pharyngitis. Clinically, RC is characterized by involuntary arrhythmic movements and cognitive and behavioral symptoms. RC supposedly results from basal ganglia dysfunction triggered by cross-reactive antibodies produced during GABHS infection. Recent studies have unveiled specific antibody targets in the basal ganglia possibly implicated in neural circuits dysfunction and, therefore, in the emergence of neurological symptoms. In this chapter, we summarize current evidence on clinical and pathophysiological aspects of RC.

KW - Autoimmune movement disorders

KW - Neuropsychiatric manifestation

KW - Rheumatic chorea

KW - Rheumatic fever

KW - Sydenham’s chorea

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Rheumatic chorea

Abstract

Keywords

ASJC Scopus subject areas

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