RGS Protein Regulation of Phototransduction

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations


First identified in yeast and worm and later in other species, the physiological importance of Regulators of G-protein Signaling (RGS) in mammals was first demonstrated at the turn of the century in mouse retinal photoreceptors, in which RGS9 is needed for timely recovery of rod phototransduction. The role of RGS in vision has also been established a synapse away in retinal depolarizing bipolar cells (DBCs), where RGS7 and RGS11 work redundantly and in a complex with Gβ5-S as GAPs for Goα in the metabotropic glutamate receptor 6 pathway situated at DBC dendritic tips. Much less is known on how RGS protein subserves vision in the rest of the visual system. The research into the roles of RGS proteins in vision holds great potential for many exciting new discoveries.

Original languageEnglish (US)
Title of host publicationProgress in Molecular Biology and Translational Science
PublisherElsevier B.V.
Number of pages15
StatePublished - 2015
Externally publishedYes

Publication series

NameProgress in Molecular Biology and Translational Science
ISSN (Print)1877-1173
ISSN (Electronic)1878-0814


  • Depolarizing bipolar cell
  • Heterotrimeric G-protein
  • Photoreceptor
  • Phototransduction
  • Rate-limiting step
  • Regulators of G-protein Signaling
  • Retina
  • Vision

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology


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