Revolutionizing orofacial pain management: the promising potential of stem cell therapy

Ke Ren, Russel Vickers, Josue Murillo, Nikita B. Ruparel

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Orofacial pain remains a significant health issue in the United States. Pain originating from the orofacial region can be composed of a complex array of unique target tissue that contributes to the varying success of pain management. Long-term use of analgesic drugs includes adverse effects such as physical dependence, gastrointestinal bleeding, and incomplete efficacy. The use of mesenchymal stem cells for their pain relieving properties has garnered increased attention. In addition to the preclinical and clinical results showing stem cell analgesia in non-orofacial pain, studies have also shown promising results for orofacial pain treatment. Here we discuss the outcomes of mesenchymal stem cell treatment for pain and compare the properties of stem cells from different tissues of origin. We also discuss the mechanism underlying these analgesic/anti-nociceptive properties, including the role of immune cells and the endogenous opioid system. Lastly, advancements in the methods and procedures to treat patients experiencing orofacial pain with mesenchymal stem cells are also discussed.

Original languageEnglish (US)
Article number1239633
JournalFrontiers in Pain Research
StatePublished - 2023


  • MSC secretome
  • mechanisms of stem cell anti-nociception
  • orofacial pain
  • stem cell analgesia
  • trigeminal pain

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Anesthesiology and Pain Medicine
  • Health Professions (miscellaneous)
  • Neuroscience (miscellaneous)


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