Revisiting the role of eotaxin-1/CCL11 in psychiatric disorders

Antonio L. Teixeira, Clarissa S. Gama, Natalia P. Rocha, Mauro M. Teixeira

Research output: Contribution to journalShort surveypeer-review

81 Scopus citations

Abstract

Eotaxin-1/CCL11 is a chemokine originally implicated in the selective recruitment of eosinophils into inflammatory sites during allergic reactions, being thoroughly investigated in asthma, allergic rhinitis, and other eosinophil-related conditions. Eotaxin-1/CCL11 is also involved with a skewed immune response toward a type-2 (Th2) profile. In addition to its role in immune response, recent studies have shown that eotaxin-1/CCL11 is associated with aging, neurogenesis and neurodegeneration, being able to influence neural progenitor cells, and microglia. Increased circulating levels of eotaxin-1/CCL11 have been described in major psychiatric disorders (schizophrenia, bipolar disorder, major depression), sometimes correlating with the severity of psychopathological and cognitive parameters. As similar findings have been reported in neurodegenerative conditions such as Alzheimer's disease, it has been hypothesized that mechanisms involving eotaxin-1/CCL11 signaling may underlie the "accelerated aging" profile commonly linked to psychiatric disorders. Future studies must determine whether eotaxin-1/CCL11 can be regarded as a prognostic biomarker and/or as therapeutic target for resistant/progressive cases.

Original languageEnglish (US)
Article number241
JournalFrontiers in Psychiatry
Volume9
Issue numberJUN
DOIs
StatePublished - Jun 14 2018
Externally publishedYes

Keywords

  • Aging
  • Alzheimer's disease
  • Bipolar disorder
  • CCL11
  • Depression
  • Eotaxin-1
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health

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