Revisiting chronodisruption: When the physiological nexus between internal and external times splits in humans

Thomas C. Erren, Russel J. Reiter

Research output: Contribution to journalArticle

33 Scopus citations


In this Concepts & Synthesis paper, we expand the definition of chronodisruption in humans by proposing that it can be operationalized as the split nexus of internal and external times. With this premise, we suggest how chronotype may be used as a temporal marker (chronomarker) of exposure to chronodisruption in studies of cancer, and beyond, offer cancer risk predictions for observational research on the basis of a chronotype-related hypothesis and corollary, and point to first empirical data in humans. In an a priori way, we examine possible outcomes and perspectives for preventive measures following from our rationale and the suggested chronobiology-driven studies and close with overall advances of chronodisruption research.

Original languageEnglish (US)
Pages (from-to)291-298
Number of pages8
Issue number4
Publication statusPublished - Apr 1 2013



  • Cancer
  • Chronodisruption
  • Chronotype
  • Disease
  • External time
  • Health
  • Internal time
  • Shift work

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics

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