Revisiting Aurora Kinase B: A promising therapeutic target for cancer therapy

Naga Rajiv Lakkaniga, Zhengyu Wang, Yao Xiao, Anupreet Kharbanda, Li Lan, Hong yu Li

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Cancer continues to be a major health concern globally, although the advent of targeted therapy has revolutionized treatment options. Aurora Kinase B is a serine-threonine kinase that has been explored as an oncology therapeutic target for more than two decades. Aurora Kinase B inhibitors show promising biological results in in-vitro and in-vivo experiments. However, there are no inhibitors approved yet for clinical use, primarily because of the side effects associated with Aurora B inhibitors. Several studies demonstrate that Aurora B inhibitors show excellent synergy with various chemotherapeutic agents, radiation therapy, and targeted therapies. This makes it an excellent choice as an adjuvant therapy to first-line therapies, which greatly improves the therapeutic window and side effect profile. Recent studies indicate the role of Aurora B in some deadly cancers with limited therapeutic options, like triple-negative breast cancer and glioblastoma. Herein, we review the latest developments in Aurora Kinase B targeted research, with emphasis on its potential as an adjuvant therapy and its role in some of the most difficult-to-treat cancers.

Original languageEnglish (US)
Pages (from-to)686-706
Number of pages21
JournalMedicinal Research Reviews
Volume44
Issue number2
DOIs
StatePublished - Mar 2024
Externally publishedYes

Keywords

  • Aurora B
  • cancer
  • inhibitor
  • kinase
  • synergy

ASJC Scopus subject areas

  • Drug Discovery
  • Molecular Medicine
  • Pharmacology

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