TY - JOUR
T1 - Revisiting Apathy in Alzheimer's Disease
T2 - From Conceptualization to Therapeutic Approaches
AU - Teixeira, Antonio L.
AU - Gonzales, Mitzi M.
AU - De Souza, Leonardo Cruz
AU - Weisenbach, Sara L.
N1 - Publisher Copyright:
© 2021 Antonio L. Teixeira et al.
PY - 2021
Y1 - 2021
N2 - Apathy is a neurobehavioral syndrome characterized by impaired motivation for goal-directed behaviors and cognitive activity, alongside blunted affect. Apathy is a common neuropsychiatric syndrome in Alzheimer's disease (AD), with a 5-year prevalence over 70%. Apathy also serves as a prognostic indicator, correlating with the progression of AD. Despite advances in its conceptualization and understanding of its neural basis, there is very limited empirical evidence to support the available strategies for the treatment of apathy in AD. Given its complex pathophysiology, including distinct substrates for different apathy dimensions (affective, cognitive, and behavioral), it is unlikely that a single pharmacological or nonpharmacological strategy will be effective for all cases of apathy in AD. High-quality evidence research is needed to better understand the role of specific strategies aiming at a personalized approach.
AB - Apathy is a neurobehavioral syndrome characterized by impaired motivation for goal-directed behaviors and cognitive activity, alongside blunted affect. Apathy is a common neuropsychiatric syndrome in Alzheimer's disease (AD), with a 5-year prevalence over 70%. Apathy also serves as a prognostic indicator, correlating with the progression of AD. Despite advances in its conceptualization and understanding of its neural basis, there is very limited empirical evidence to support the available strategies for the treatment of apathy in AD. Given its complex pathophysiology, including distinct substrates for different apathy dimensions (affective, cognitive, and behavioral), it is unlikely that a single pharmacological or nonpharmacological strategy will be effective for all cases of apathy in AD. High-quality evidence research is needed to better understand the role of specific strategies aiming at a personalized approach.
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U2 - 10.1155/2021/6319826
DO - 10.1155/2021/6319826
M3 - Review article
C2 - 34394772
AN - SCOPUS:85113178731
VL - 2021
JO - Behavioural Neurology
JF - Behavioural Neurology
SN - 0953-4180
M1 - 6319826
ER -