Review of T-2307, an investigational agent that causes collapse of fungal mitochondrial membrane potential

Nathan P. Wiederhold

Research output: Contribution to journalArticlepeer-review

Abstract

Invasive infections caused by Candida that are resistant to clinically available antifungals are of increasing concern. Increasing rates of fluconazole resistance in non-albicans Candida species have been documented in multiple countries on several continents. This situation has been further exacerbated over the last several years by Candida auris, as isolates of this emerging pathogen that are often resistant to multiple antifungals. T-2307 is an aromatic diamidine currently in development for the treatment of invasive fungal infections. This agent has been shown to selectively cause the collapse of the mitochondrial membrane potential in yeasts when compared to mammalian cells. In vitro activity has been demonstrated against Candida species, including C. albicans, C. glabrata, and C. auris strains, which are resistant to azole and echinocandin antifungals. Activity has also been reported against Cryptococcus species, and this has translated into in vivo efficacy in experimental models of invasive candidiasis and cryptococcosis. However, little is known regarding the clinical efficacy and safety of this agent, as published data from studies involving humans are not currently available.

Original languageEnglish (US)
Article number130
Pages (from-to)1-9
Number of pages9
JournalJournal of Fungi
Volume7
Issue number2
DOIs
StatePublished - Feb 2021

Keywords

  • Aromatic diamidine
  • Candida
  • Cryptococcus
  • In vitro susceptibility
  • Mitochondrial membrane
  • Mitochondrial membrane potential
  • T-2307

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Plant Science
  • Microbiology (medical)

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