Reverse Genetics Applied to Immunobiology of Tumor Necrosis Factor, a Multifunctional Cytokine

Sergey A. Nedospasov; Andrei A. Kruglov; Alexei V. Tumanov; Marina S. Drutskaya; Irina V. Astrakhantseva; Dmitry V. Kuprash

doi:10.1134/S0006297924050067

Reverse Genetics Applied to Immunobiology of Tumor Necrosis Factor, a Multifunctional Cytokine

Sergey A. Nedospasov, Andrei A. Kruglov, Alexei V. Tumanov, Marina S. Drutskaya, Irina V. Astrakhantseva, Dmitry V. Kuprash

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

Abstract: Tumor necrosis factor (TNF) is one of many cytokines – protein molecules responsible for communication between the cells of immune system. TNF was discovered and given its grand name because of its striking antitumor effects in experimental systems, but its main physiological functions in the context of whole organism turned out to be completely unrelated to protection against tumors. This short review discusses “man-made” mouse models generated by early genome-editing technologies, which enabled us to establish true functions of TNF in health and certain diseases as well as to unravel potential strategies for improving therapy of TNF-dependent diseases.

Original language	English (US)
Pages (from-to)	853-861
Number of pages	9
Journal	Biochemistry (Moscow)
Volume	89
Issue number	5
DOIs	https://doi.org/10.1134/S0006297924050067
State	Published - May 2024
Externally published	Yes

Keywords

conditional mice models
gene knockout
gene overexpression
reporter mice
TNF
tumor necrosis factor

ASJC Scopus subject areas

Biophysics
Biochemistry
Biochemistry, Genetics and Molecular Biology (miscellaneous)
Geriatrics and Gerontology

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10.1134/S0006297924050067

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title = "Reverse Genetics Applied to Immunobiology of Tumor Necrosis Factor, a Multifunctional Cytokine",

abstract = "Abstract: Tumor necrosis factor (TNF) is one of many cytokines – protein molecules responsible for communication between the cells of immune system. TNF was discovered and given its grand name because of its striking antitumor effects in experimental systems, but its main physiological functions in the context of whole organism turned out to be completely unrelated to protection against tumors. This short review discusses “man-made” mouse models generated by early genome-editing technologies, which enabled us to establish true functions of TNF in health and certain diseases as well as to unravel potential strategies for improving therapy of TNF-dependent diseases.",

keywords = "conditional mice models, gene knockout, gene overexpression, reporter mice, TNF, tumor necrosis factor",

author = "Nedospasov, {Sergey A.} and Kruglov, {Andrei A.} and Tumanov, {Alexei V.} and Drutskaya, {Marina S.} and Astrakhantseva, {Irina V.} and Kuprash, {Dmitry V.}",

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doi = "10.1134/S0006297924050067",

language = "English (US)",

volume = "89",

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journal = "Biochemistry (Moscow)",

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T1 - Reverse Genetics Applied to Immunobiology of Tumor Necrosis Factor, a Multifunctional Cytokine

AU - Nedospasov, Sergey A.

AU - Kruglov, Andrei A.

AU - Tumanov, Alexei V.

AU - Drutskaya, Marina S.

AU - Astrakhantseva, Irina V.

AU - Kuprash, Dmitry V.

N1 - Publisher Copyright: © Pleiades Publishing, Ltd. 2024.

PY - 2024/5

Y1 - 2024/5

N2 - Abstract: Tumor necrosis factor (TNF) is one of many cytokines – protein molecules responsible for communication between the cells of immune system. TNF was discovered and given its grand name because of its striking antitumor effects in experimental systems, but its main physiological functions in the context of whole organism turned out to be completely unrelated to protection against tumors. This short review discusses “man-made” mouse models generated by early genome-editing technologies, which enabled us to establish true functions of TNF in health and certain diseases as well as to unravel potential strategies for improving therapy of TNF-dependent diseases.

AB - Abstract: Tumor necrosis factor (TNF) is one of many cytokines – protein molecules responsible for communication between the cells of immune system. TNF was discovered and given its grand name because of its striking antitumor effects in experimental systems, but its main physiological functions in the context of whole organism turned out to be completely unrelated to protection against tumors. This short review discusses “man-made” mouse models generated by early genome-editing technologies, which enabled us to establish true functions of TNF in health and certain diseases as well as to unravel potential strategies for improving therapy of TNF-dependent diseases.

KW - conditional mice models

KW - gene knockout

KW - gene overexpression

KW - reporter mice

KW - TNF

KW - tumor necrosis factor

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Reverse Genetics Applied to Immunobiology of Tumor Necrosis Factor, a Multifunctional Cytokine

Abstract

Keywords

ASJC Scopus subject areas

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