Reversal of nitroglycerin tolerance in coronary artery disease

D. C. May; L. D. Hillis

Reversal of nitroglycerin tolerance in coronary artery disease

D. C. May, L. D. Hillis

Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Tolerance to a sustained infusion of nitroglycerin is known to develop in patients being treated for angina pectoris. The mechanism by which this occurs is not well understood, but is linked to molecular changes in vascular smooth muscle cells. Our study showed that tolerance to nitroglycerin develops in coronary arteries and that it can be reversed by introducing a sulfhydryl-rich compound, N-acetylcysteine.

Original language	English (US)
Pages (from-to)	132-133+137-138+141-142
Journal	Cardiology Board Review
Volume	5
Issue number	3
State	Published - Jan 1 1988

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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title = "Reversal of nitroglycerin tolerance in coronary artery disease",

abstract = "Tolerance to a sustained infusion of nitroglycerin is known to develop in patients being treated for angina pectoris. The mechanism by which this occurs is not well understood, but is linked to molecular changes in vascular smooth muscle cells. Our study showed that tolerance to nitroglycerin develops in coronary arteries and that it can be reversed by introducing a sulfhydryl-rich compound, N-acetylcysteine.",

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