Reversal of nitroglycerin tolerance in coronary artery disease

D. C. May, L. D. Hillis

Research output: Contribution to journalArticlepeer-review


Tolerance to a sustained infusion of nitroglycerin is known to develop in patients being treated for angina pectoris. The mechanism by which this occurs is not well understood, but is linked to molecular changes in vascular smooth muscle cells. Our study showed that tolerance to nitroglycerin develops in coronary arteries and that it can be reversed by introducing a sulfhydryl-rich compound, N-acetylcysteine.

Original languageEnglish (US)
Pages (from-to)132-133+137-138+141-142
JournalCardiology Board Review
Issue number3
StatePublished - Jan 1 1988

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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