Tolerance to a sustained infusion of nitroglycerin is known to develop in patients being treated for angina pectoris. The mechanism by which this occurs is not well understood, but is linked to molecular changes in vascular smooth muscle cells. Our study showed that tolerance to nitroglycerin develops in coronary arteries and that it can be reversed by introducing a sulfhydryl-rich compound, N-acetylcysteine.
|Original language||English (US)|
|Journal||Cardiology Board Review|
|State||Published - Jan 1 1988|
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine