Reversal of nitroglycerin tolerance in coronary artery disease

D. C. May, L. D. Hillis

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Tolerance to a sustained infusion of nitroglycerin is known to develop in patients being treated for angina pectoris. The mechanism by which this occurs is not well understood, but is linked to molecular changes in vascular smooth muscle cells. Our study showed that tolerance to nitroglycerin develops in coronary arteries and that it can be reversed by introducing a sulfhydryl-rich compound, N-acetylcysteine.

Original languageEnglish (US)
Title of host publicationCardiology Board Review
Volume5
Edition3
StatePublished - 1988
Externally publishedYes

Fingerprint

Nitroglycerin
Coronary Artery Disease
Acetylcysteine
Angina Pectoris
Vascular Smooth Muscle
Sulfhydryl Compounds
Smooth Muscle Myocytes
Coronary Vessels

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

May, D. C., & Hillis, L. D. (1988). Reversal of nitroglycerin tolerance in coronary artery disease. In Cardiology Board Review (3 ed., Vol. 5)

Reversal of nitroglycerin tolerance in coronary artery disease. / May, D. C.; Hillis, L. D.

Cardiology Board Review. Vol. 5 3. ed. 1988.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

May, DC & Hillis, LD 1988, Reversal of nitroglycerin tolerance in coronary artery disease. in Cardiology Board Review. 3 edn, vol. 5.
May DC, Hillis LD. Reversal of nitroglycerin tolerance in coronary artery disease. In Cardiology Board Review. 3 ed. Vol. 5. 1988
May, D. C. ; Hillis, L. D. / Reversal of nitroglycerin tolerance in coronary artery disease. Cardiology Board Review. Vol. 5 3. ed. 1988.
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