Retinotopic organization of human visual cortex mapped with positron-emission tomography

P. T. Fox, F. M. Miezin, J. M. Allman, D. C. Van Essen, M. E. Raichle

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Abstract

The retinotopic organization of primary visual cortex was mapped in normal human volunteers. Positron-emission tomographic measurements of regional cerebral blood flow were employed to detect focal functional brain activation. Oxygen-15-labeled water, delivered by intravenous bolus, was used as the blood flow tracer to allow multiple stimulated-state (n = 5) and control-state (n = 3) measurements to be acquired for each of 7 subjects. Responses were identified by applying a maximum-detection algorithm to subtraction-format images of the stimulus-induced change in cerebral blood flow. Response locales were described using a standardized system of stereotactic coordinates. Changes in stimulus location (macular, perimacular, peripheral, upper-field, lower-field) caused systematic, highly significant changes in response locale witin visual cortex. Discrete extrastriate visual responses were also observed.

Original languageEnglish (US)
Pages (from-to)913-922
Number of pages10
JournalJournal of Neuroscience
Volume7
Issue number3
Publication statusPublished - Sep 10 1987

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ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Fox, P. T., Miezin, F. M., Allman, J. M., Van Essen, D. C., & Raichle, M. E. (1987). Retinotopic organization of human visual cortex mapped with positron-emission tomography. Journal of Neuroscience, 7(3), 913-922.