Retinal lipid peroxidation in vitro is inhibited by melatonin

L. D. Chen; D. Melchiorri; E. Sewerynek; R. J. Reiter

Retinal lipid peroxidation in vitro is inhibited by melatonin

L. D. Chen, D. Melchiorri, E. Sewerynek, R. J. Reiter

Cell Systems & Anatomy

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Retinal homogenates from albino rats were incubated at 37°C, with or without the pineal hormone melatonin, FeSO₄, or melatonin plus FeSO₄. Melatonin significantly diminished the increase in malonaldehyde + 4-hydroxyalkenals levels, an index of lipid peroxidation, both in the presence as well as in the absence of FeSO₄. Melatonin protection against lipid peroxidation is probably due to the newly discovered antioxidant activity of this indolamine.

Original language	English (US)
Pages (from-to)	151-158
Number of pages	8
Journal	Neuroscience Research Communications
Volume	17
Issue number	3
State	Published - Jan 1 1995

Keywords

Lipid peroxidation
Melatonin
Retina

ASJC Scopus subject areas

Neuroscience(all)

Cite this

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AU - Melchiorri, D.

AU - Sewerynek, E.

AU - Reiter, R. J.

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N2 - Retinal homogenates from albino rats were incubated at 37°C, with or without the pineal hormone melatonin, FeSO4, or melatonin plus FeSO4. Melatonin significantly diminished the increase in malonaldehyde + 4-hydroxyalkenals levels, an index of lipid peroxidation, both in the presence as well as in the absence of FeSO4. Melatonin protection against lipid peroxidation is probably due to the newly discovered antioxidant activity of this indolamine.

AB - Retinal homogenates from albino rats were incubated at 37°C, with or without the pineal hormone melatonin, FeSO4, or melatonin plus FeSO4. Melatonin significantly diminished the increase in malonaldehyde + 4-hydroxyalkenals levels, an index of lipid peroxidation, both in the presence as well as in the absence of FeSO4. Melatonin protection against lipid peroxidation is probably due to the newly discovered antioxidant activity of this indolamine.

KW - Lipid peroxidation

KW - Melatonin

KW - Retina

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Retinal lipid peroxidation in vitro is inhibited by melatonin

Abstract

Keywords

ASJC Scopus subject areas

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