Retinal lipid peroxidation in vitro is inhibited by melatonin

L. D. Chen; D. Melchiorri; E. Sewerynek; R. J. Reiter

Retinal lipid peroxidation in vitro is inhibited by melatonin

L. D. Chen, D. Melchiorri, E. Sewerynek, R. J. Reiter

Cell Systems & Anatomy

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Retinal homogenates from albino rats were incubated at 37°C, with or without the pineal hormone melatonin, FeSO₄, or melatonin plus FeSO₄. Melatonin significantly diminished the increase in malonaldehyde + 4-hydroxyalkenals levels, an index of lipid peroxidation, both in the presence as well as in the absence of FeSO₄. Melatonin protection against lipid peroxidation is probably due to the newly discovered antioxidant activity of this indolamine.

Original language	English (US)
Pages (from-to)	151-158
Number of pages	8
Journal	Neuroscience Research Communications
Volume	17
Issue number	3
State	Published - Jan 1 1995

Keywords

Lipid peroxidation
Melatonin
Retina

ASJC Scopus subject areas

Neuroscience(all)

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AU - Melchiorri, D.

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KW - Melatonin

KW - Retina

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